Cell proliferation and outcome following doxorubicin plus CMF regimens in node-positive breast cancer
In: International Symposium on Biology of Cancer Prevention and TreatmentInternational journal of cancer 87(3):405-411; Jg. 87 (2000) 3, S. 405-411
Online
Konferenz
- print, 26 ref
Zugriff:
At the Istituto Nazionale Tumori of Milan, a randomised adjuvant chemotherapy trial was carried out from 1982 to 1990 to compare alternating with sequential regimens of doxorubicin and CMF in 403 patients with more than 3 positive axillary nodes. Tumour proliferative activity was determined in 71% (285 cases) of women entering the clinical study. We investigated the relation between proliferative rate, determined as the [3H]thymidine labelling index (TLI) on tumour specimens obtained at diagnostic surgery, and clinical outcome following the 2 regimens, in which the same drugs were administered at the same dose intensity but with a different schedule. A high TLI was significantly associated with 12-year overall relapse (P = 0.009), distant metastasis (P = 0.001), and death (P = 0.002), even in the presence of information provided by tumour size, lymph node involvement, oestrogen receptors, and treatment regimen. The highest relapse-free survival (RFS) probability (45%, 95% Cl 34-55%) was observed for patients with tumour TLI <5% and subjected to the sequential treatment. The lowest RFS probability (11%, 95% Cl 0-26%) was observed for patients with tumour TLI >9% following the alternating regimen. Intermediate RFS probabilities, ranging from 23% to 34%, were observed for the other kinetic subgroups following the 2 treatment regimens. The benefit of sequential administration of doxorubicin and CMF was evident mainly in patients with tumours at low to intermediate proliferation.
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Cell proliferation and outcome following doxorubicin plus CMF regimens in node-positive breast cancer
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Autor/in / Beteiligte Person: | SILVESTRINI, R ; LUISI, A ; ZAMBETTI, M ; CIPRIANI, S ; VALAGUSSA, P ; BONADONNA, G ; DAIDONE, M. G |
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Quelle: | International Symposium on Biology of Cancer Prevention and TreatmentInternational journal of cancer 87(3):405-411; Jg. 87 (2000) 3, S. 405-411 |
Veröffentlichung: | New York, NY: Wiley-Liss, 2000 |
Medientyp: | Konferenz |
Umfang: | print, 26 ref |
ISSN: | 0020-7136 (print) |
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