The first, second, third and fourth order Markov chain analysis on the amino-acid sequence of human dopamine β-hydroxylase
In: Molecular psychiatry, Jg. 5 (2000), Heft 4, S. 448-451
Online
academicJournal
- print, 10 ref
Zugriff:
The repeated amino-acid sequences in human dopamine β-hydroxylase (DBH) may be indispensable for DBH activity, because such repetitions cannot be simply attributed to random chance. The amino acid sequence of human DBH was analysed according to two-, three-, four- and five-amino-acid sequences and their probabilities in human DBH were calculated. The first, second, third and fourth order Markov chain was used to calculate the transition probability for two-, three-, four- and five-amino-acid sequences. The longest repeated sequence is glycine-isoleucine-leucine-glutamic acid-glutamic acid, which appears twice in DBH. The results suggest that the amino acids with a high Markov transition probability may serve as the potential targets of new drugs, because they are unlikely to change into other amino acids.
Titel: |
The first, second, third and fourth order Markov chain analysis on the amino-acid sequence of human dopamine β-hydroxylase
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Autor/in / Beteiligte Person: | WU, G |
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Zeitschrift: | Molecular psychiatry, Jg. 5 (2000), Heft 4, S. 448-451 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2000 |
Medientyp: | academicJournal |
Umfang: | print, 10 ref |
ISSN: | 1359-4184 (print) |
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