A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxy-methane-induction of colon cancers in male F344 rats
In: Oncology reports, Jg. 10 (2003), Heft 2, S. 375-379
academicJournal
- print, 33 ref
Zugriff:
The present study was designed to investigate the protective effect of a dietary water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi or Mannentake) mycelia (designated as MAK) on the induction and development of azoxymethane (AOM)-induced colon tumors in male F344/Du Crj rats. A total of 80 animals were divided into five groups at six weeks of age, groups 2, 3 and 4 being given weekly subcutaneous injections of AOM (15 mg/ kg body weight) for the initial 3 weeks to induce colon tumors. Rats in group 1 and 5 were injected with the vehicle, 0.9% (w/v) saline, following the same schedule. Rats in groups 1, 2, 3, 4 and 5 were fed MF, MF, 1.25% MAK, 2.5% MAK and 2.5% MAK diets, respectively, starting 1 week before AOM treatment and throughout the six-month experimental period. There were no significant differences in number of ACF, total AC and AC per site among groups 2 to 4, but the tumor incidence was significantly lower, and tumor size was smaller in group 4 (AOM + 2.5% MAK) than in group 2 (AOM + MF). Additionally, β-catenin positive tumor cell nuclei were significantly decreased in the MAK-fed rats (groups 3 and 4), which also demonstrated lowering of the PCNA labeling index and a shortened germinal region in the colon. The present results thus indicate that dietary MAK could act as a potent chemopreventive agent for colon carcinogenesis.
Titel: |
A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxy-methane-induction of colon cancers in male F344 rats
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Autor/in / Beteiligte Person: | LU, Huimei ; KYO, Eikai ; UESAKA, Toshihiro ; KATOH, Osamu ; WATANABE, Hiromitsu |
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Zeitschrift: | Oncology reports, Jg. 10 (2003), Heft 2, S. 375-379 |
Veröffentlichung: | Athens: [S.n.], 2003 |
Medientyp: | academicJournal |
Umfang: | print, 33 ref |
ISSN: | 1021-335X (print) |
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