No association between A polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics
In: Alcohol and alcoholism (Oxford), Jg. 38 (2003), Heft 1, S. 31-34
Online
academicJournal
- print, 35 ref
Zugriff:
Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability. Buss Durkee Assault and Barrat Impulsiveness Score was conducted. Results: High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. Conclusions: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
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No association between A polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics
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Autor/in / Beteiligte Person: | KOLLER, G ; BONDY, B ; PREUSS, U. W ; BOTTLENDER, M ; SOYKA, M |
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Zeitschrift: | Alcohol and alcoholism (Oxford), Jg. 38 (2003), Heft 1, S. 31-34 |
Veröffentlichung: | Oxford: Oxford University Press, 2003 |
Medientyp: | academicJournal |
Umfang: | print, 35 ref |
ISSN: | 0735-0414 (print) |
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