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Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/ or in particular occupations.

Titel:	Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study
Autor/in / Beteiligte Person:	DUCOMBS, G ; LEPOITTEVIN, J. P ; LACHAPELLE, J. M ; LAHTI, A ; LE COZ, C. J ; MAIBACH, H. I ; MENNE, T ; SEIDENARI, S ; SHAW, S ; TOSTI, A ; WILKINSON, J. D ; BERL, V ; ANDERSEN, K. E ; BRANDAO, F. M ; BRUYNZEEL, D. P ; BRUZE, M ; CAMARASA, J. G ; FROSCH, P. J ; GOOSSENS, A
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Contact dermatitis, Jg. 48 (2003), Heft 3, S. 158-161
Veröffentlichung:	Oxford: Blackwell, 2003
Medientyp:	academicJournal
Umfang:	print, 20 ref
ISSN:	0105-1873 (print)
Schlagwort:	Dermatology Dermatologie Immunology, immunopathology, allergology Immunologie, immunopathologie, allergologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Toxicologie Toxicology Toxicologie des poisons d'origine végétale Plant poisons toxicology Immunopathologie Immunopathology Maladies allergiques Allergic diseases Dermatoses allergiques. Allergie aux piqûres d'insectes Skin allergic diseases. Stinging insect allergies Angiospermae Dicotyledones Inmunopatología Peau pathologie Skin disease Piel patología Spermatophyta Allergie Allergy Alergia Compositae Dermatite contact Contact dermatitis Dermatitis de contacto Homme Human Hombre Lactone Lactona Lauraceae Origine végétale Plant origin Origen vegetal Patch Parche Sesquiterpène Sesquiterpenes Sesquiterpeno Test cutané Skin test Prueba cutáneo Toxicité Toxicity Toxicidad Frullania Frullanolide Asteraceae (Compositae) allergic contact dermatitis frullanolide plants sesquiterpene lactones
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Dermatology, CHU de Bordeaux, Hôpital Saint André, Bordeaux, France ; Laboratoire de Dermatochimie, Université Louis Pasteur, Clinique Dermatologique, CHU, Strasbourg, France ; Unit of Occupational and Environmental Dermatology, Louvain University UCL, Bruxelles, Belgium ; Department of Dermatology, University of Oulu, Oulu, Finland ; Clinique Dermatologique, CHU, Strasbourg, France ; Department of Dermatology, UCSF, School of Medicine, San Francisco, CA, United States ; Department of Dermatology, Gentofte Hospital, Copenhagen, Denmark ; Department of Dermatology, University of Modena, Modena, Italy ; Department of Dermatology, Amersham General Hospital, Bucks, United Kingdom ; Department of Dermatology, University of Bologna, Bologna, Italy ; Department of Dermatology, Odense University Hospital, Odense, Denmark ; Department of Dermatology, Hospital Garcia de Orta, Almada, Portugal ; Department of Dermatology, Free University Hospital, Amsterdam, Netherlands ; Department of Occupational and Environmental Dermatology, University Hospital Malmö, Malmö, Sweden ; Servicio de Dermatologia, Hospital del Mar, Paseo maritimo, Barcelona, Spain ; Department of Dermatology, Städtische Kliniken, Dortmund and University of Witten/Herdecke, Germany ; Dermatology/Contact Allergy, Katholieke Universiteit Leuven, Leuven, Belgium Rights: Copyright 2003 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Immunopathology ; Toxicology

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Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study