LC determination of impurities in azithromycin tablets
In: Journal of pharmaceutical and biomedical analysis, Jg. 33 (2003), Heft 2, S. 211-217
academicJournal
- print, 14 ref
Zugriff:
A LC method with UV detection for determining azithromycin impurities in tablets as pharmaceutical form has been developed. It is to be employed in routine and stability tests. A linear gradient elution was employed starting with 47% A and 53% B to reach 28% A and 72% B at 48 min. Mobile phase A was KH2PO4 10 mM (H2O) at pH 7.00. B was a mixture methanol:acetonitrile 1:1 (v/v). UV detection was performed at 210 nm. The chromatographic column was Phenomenex Synergi® MAX-RP 4 μm 250 x 460 mm kept at 50°C. Six impurities were separated and identified and it was possible to quantify five out of the six with reasonable accuracy and precision.
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LC determination of impurities in azithromycin tablets
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Autor/in / Beteiligte Person: | MIGUEL, L ; BARBAS, C |
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Zeitschrift: | Journal of pharmaceutical and biomedical analysis, Jg. 33 (2003), Heft 2, S. 211-217 |
Veröffentlichung: | Amsterdam: Elsevier Science, 2003 |
Medientyp: | academicJournal |
Umfang: | print, 14 ref |
ISSN: | 0731-7085 (print) |
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