Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma
In: Virchows Archiv, Jg. 443 (2003), Heft 5, S. 635-642
Online
academicJournal
- print, 33 ref
Zugriff:
Sarcomatoid carcinoma of the esophagus is an unusual type of squamous cell carcinoma (SCC) with a variable component of sarcomatoid spindle cells (SA). The loss of heterozygosity (LOH) involving multiple cancer-associated chromosomal arms has been reported to have a concerted, rather than an individual, effect on tumor progression. In order to delineate the role of LOH in the evolution of a biphasic tumor, the carcinoma in situ (CIS), invasive squamous cell carcinoma (ISCC), and SA components from a sarcomatoid carcinoma of the esophagus were compared for their clonality and extent of LOH. Forty microsatellite markers on the cancer-associated chromosomes, 3p, 4p, 5q, 8p, 9p, 13q, 17p, and 18q, were used for the polymerase chain reaction-based LOH analysis. All eight sarcomatoid carcinomas tested revealed extensive LOHs, involving an average of seven chromosomal arms. All CIS, ISCC, and SA components carried not only a high-level primary LOH (mean chromosomal involvement, 5.3) in common but also a low-level secondary LOH (mean chromosomal involvement, 1.8) in disparity. Interestingly, more secondary LOHs were always burdened in the CIS (four cases) rather than the matched ISCC. SA had a greater (four cases), equal (one case), or fewer (one case) number of secondary LOHs than ISCC. Given that excessive chromosomal losses may confer a disadvantage for tumor growth or a benefit for a metaplastic transformation, these results suggest that the multidirectional differentiation of a SCC precursor is stimulated by extensive and divergent LOHs acquired at the initial or early stages, and a precursor burdened with excessive LOH either remains in CIS or expands as a SA component.
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Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma
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Autor/in / Beteiligte Person: | KWON, Mi-Seon ; HONG, Seung-Jin ; CHO, Hyun-A ; AHN, Geung-Hwan ; LEE, Seung-Sook ; LEE, Kyo-Young ; RHYU, Mun-Gan |
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Zeitschrift: | Virchows Archiv, Jg. 443 (2003), Heft 5, S. 635-642 |
Veröffentlichung: | Berlin: Springer, 2003 |
Medientyp: | academicJournal |
Umfang: | print, 33 ref |
ISSN: | 0945-6317 (print) |
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