Hormonal therapy and radiotherapy for localized prostate cancer: Who, where and how long? Discussion
In: Proceedings of the third international conference on innovations and challenges in prostate cancer: prevention, detection and treatmentThe Journal of urology 170(6):S35-S41; Jg. 170 (2003) 6, S. S35- (7S.)
Konferenz
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Zugriff:
Purpose: The results from recent randomized trials were used to identify subpopulations of patients most likely to benefit from long versus short-term hormonal therapy with external beam radiotherapy. Materials and Methods: Radiation Therapy Oncology Group study 9413 included 1,323 men with prostate cancer and a risk of lymph node involvement greater than 15%. In this study the hypotheses tested were that whole pelvis radiotherapy would improve progression-free survival (PFS) compared to prostate only radiotherapy and that neoadjuvant and concurrent hormone therapy (N&CHT) with radiotherapy would improve PFS compared to radiotherapy with adjuvant hormone therapy. The conclusions of this study were compared to other studies using long-term hormonal therapy. Results: At a median followup of almost 5 years, when all 4 treatment arms from study 9413 were compared, the group receiving whole pelvis radiotherapy plus N&CHT had a significant PFS advantage (p = 0.008). Conclusions: Intermediate risk patients should receive N&CHT in combination with external beam radiotherapy while high risk patients require the addition of long-term adjuvant hormone therapy.
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Hormonal therapy and radiotherapy for localized prostate cancer: Who, where and how long? Discussion
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Autor/in / Beteiligte Person: | ROACH, Mack III ; KANTOFF, Philip W ; D'AMICO, Anthony V ; HIGANO, Celestia S |
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Quelle: | Proceedings of the third international conference on innovations and challenges in prostate cancer: prevention, detection and treatmentThe Journal of urology 170(6):S35-S41; Jg. 170 (2003) 6, S. S35- (7S.) |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2003 |
Medientyp: | Konferenz |
Umfang: | print, 20 ref 2 |
ISSN: | 0022-5347 (print) |
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