Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma

ECK, M ; SCHMAUSSER, B ; et al.

In: Clinical and experimental immunology (Print), Jg. 134 (2003), Heft 3, S. 508-515

Online academicJournal - print, 28 ref

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CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal- and diffuse-type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)-8], CXCL1 [growth-related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)-γ] and CXCL10 [IFN-γ-inducible protein-10 (IP-10)] and the corresponding chemokine receptors CXCR1-3 was investigated by immunohistochemistry in intestinal- and diffuse-type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse- rather than intestinal-type gastric carcinoma (P < 0.01) as determined by a semiquantitative score. CXCL1 was expressed almost exclusively by diffuse- but not intestinal-type carcinoma cells. The corresponding chemokine receptors, CXCR1 and CXCR2. were found on carcinoma cells. Furthermore, CXCL8 expression correlated with number of tumour vessels (P < 0.01), suggesting an angiogenetic function in gastric carcinoma not only in vitro but also in vivo. CXCL10 and CXCL9, attractants for T cells, were expressed by peritumorous macrophages in close proximity to IFN-γ-producing CXCR3-positive T cells in both tumour types. These chemokines may attract gastric carcinomainfiltrating T cells via an IFN-γ-mediated pathway and enhance host immunity against the tumour. In gastric carcinoma a complex interplay between CXC-chemokine signals derived from both tumour cells and tumour-infiltrating immune cells may exhibit pleiotropic effects in tumour biology that go far beyond their originally described functions as leucocyte chemoattractants. Because CXCL8 and CXCL1. which are known to increase growth and invasive behaviour of malignant tumours, are significantly stronger expressed in diffuse- than intestinal-type gastric carcinoma, one may speculate that these chemokines influence the different growth pattern of gastric carcinoma types.

Titel:	Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
Autor/in / Beteiligte Person:	ECK, M ; SCHMAUSSER, B ; SCHELLER, K ; BRÄNDLEIN, S ; MÜLLER-HERMELINK, H. K
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Clinical and experimental immunology (Print), Jg. 134 (2003), Heft 3, S. 508-515
Veröffentlichung:	Oxford: Blackwell, 2003
Medientyp:	academicJournal
Umfang:	print, 28 ref
ISSN:	0009-9104 (print)
Schlagwort:	Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Immunology, immunopathology, allergology Immunologie, immunopathologie, allergologie General medicine general surgery Médecine et chirurgie générales Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Gastroenterologie. Foie. Pancreas. Abdomen Gastroenterology. Liver. Pancreas. Abdomen Estomac. Duodénum. Intestin grêle. Côlon. Rectum. Anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumeurs Tumors Appareil digestif pathologie Digestive diseases Aparato digestivo patología Cytokine Citoquina Estomac pathologie Gastric disease Estómago patología Tumeur maligne Malignant tumor Tumor maligno Carcinome Carcinoma Chimiokine CXC CXC chemokine Quimioquina CXC Estomac Stomach Estómago Homme Human Hombre Pathogénie Pathogenesis Patogenia Récepteur biologique Biological receptor Receptor biológico Récepteur chimiokine CXCR1 CXCR1 chemokine receptor Receptor quimioquina CXCR1 Récepteur chimiokine CXCR2 CXCR2 chemokine receptor Receptor quimioquina CXCR2 Récepteur chimiokine CXCR3 CXCR3 chemokine receptor Receptor quimioquina CXCR3 chemokine receptors CXC chemokines gastric carcinoma
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Institut für Pathologie, Universität Würzburg, Germany Rights: Copyright 2004 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Gastroenterology. Liver. Pancreas. Abdomen

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