Effect of epigallocatechin gallate on renal function in cyclosporine-induced nephrotoxicity
In: Proceedings of the 8th Congress of the Asian Society of Transplantation. Part One of TwoTransplantation proceedings 36(7):2133-2134; Jg. 36 (2004) 7, S. 2133-2134
Konferenz
- print, 12 ref
Zugriff:
Introduction. Nephrotoxicity is a clinically important side effect of cyclosporine (CsA). CsA-induced nephrotoxicity results from increased production of free radical species in the kidney. Epigallocatechin gallate (EGCG) acts as an antioxidant, thus, EGCG may have a protective effect on the alteration of renal function resultant from oxygen free radicals. The purpose of the present study was to investigate the protective effect of EGCG in a rodent model. Methods. Experiments were performed on 3 groups. The normal control group (group 1) received normal saline solution. The CsA-treated group (group 2; 15 mg/kg body weight/d for 14 days) received subcutaneous injections. The EGCG-treated group (group 3) in addition received 25 mg of EGCG/kg body weight by intraperitoneal injection. Results. There were significant increases in levels of blood urea nitrogen (BUN) (42.8 ± 8.2 mg/dL; P <.001), serum creatinine (1.18 ± 0.60 mg/dL; P <.05), and serum malondialdehyde (3.09 ± 0.20 nmol/mL; P <.001), and a significant decrease in CCr (0.07 ± 0.02 mL/min; P <.001) in group 2 compared with group 1. Levels of BUN (30.2 ± 0.7 mg/dL; P <.01) and CCr (0.12 ± 0.08 mL/min) were lower in group 3 than in group 2. Serum creatinine (0.71 ± 0.04 mg/dL) and serum malondialdehyde level (2.13 ± 0.15; P < .001 nmol/mL) were lower in group 3 than in group 2. There was no significant difference in CsA levels between group 2 (6.86 ± 1.48 μg/mL) and group 3 (6.69 ± 0.62 μg/mL). Conclusions. EGCG treatment significantly protected renal function and free radical-mediated injury in the kidney from CsA-induced changes.
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Effect of epigallocatechin gallate on renal function in cyclosporine-induced nephrotoxicity
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Autor/in / Beteiligte Person: | CHANG, E. J ; MUN, K. C |
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Quelle: | Proceedings of the 8th Congress of the Asian Society of Transplantation. Part One of TwoTransplantation proceedings 36(7):2133-2134; Jg. 36 (2004) 7, S. 2133-2134 |
Veröffentlichung: | New York, NY: Elsevier Science, 2004 |
Medientyp: | Konferenz |
Umfang: | print, 12 ref |
ISSN: | 0041-1345 (print) |
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