Loss of heterozygosity (LOH) in non-small cell lung cancer: difference between adenocarcinoma and squamous cell carcinoma

YOSHINO, Ichiro ; OSOEGAWA, Atsushi ; et al.

In: Respiratory medicine, Jg. 99 (2005), Heft 3, S. 308-312

Online academicJournal - print, 23 ref

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Background: In non-small cell lung cancer, a loss of heterozygosity (LOH) is frequently observed; however, few studies have investigated the differences in the LOH status between adenocarcinoma and squamous cell carcinoma. Patients and methods: In a consecutive series of 49 patients with adenocarcinomas and 22 patients with squamous cell carcinomas, the LOH in tumors was analyzed using polymerase chain reaction employing 5 fluorescence-labeled dinucleotide markers (D2S123, D5S107, D10S197, D11SS904, D13S175) and an autosequencer. Results: LOH was more frequently observed in squamous cell carcinoma (20 of 22, 90%) than in adenocarcinomas (33 of 49, 67%) (P = 0.0348), and the number of LOH per patient was also higher in the patients with squamous cell carcinoma (2.2±1.4) than in those with adenocarcinoma (1.5±1.2, P = 0.037). In adenocarcinomas, the number of LOH per patients correlated significantly with the pack-year index, whereas the pathological stage significantly affected the number of LOH in squamous cell carcinomas. Conclusion: The presence of LOH is relatively uncommon in adenocarcinoma of the lung; however, the incidence of LOH tends to be associated with the smoking status.

Titel:	Loss of heterozygosity (LOH) in non-small cell lung cancer: difference between adenocarcinoma and squamous cell carcinoma
Autor/in / Beteiligte Person:	YOSHINO, Ichiro ; OSOEGAWA, Atsushi ; YOHENA, Tomofumi ; KAMEYAMA, Toshifumi ; OKIA, Eiji ; ODA, Shinya ; MAEHARA, Yoshihiko
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Respiratory medicine, Jg. 99 (2005), Heft 3, S. 308-312
Veröffentlichung:	Oxford: Elsevier, 2005
Medientyp:	academicJournal
Umfang:	print, 23 ref
ISSN:	0954-6111 (print)
Schlagwort:	Pneumology Pneumologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Tumeurs de l'appareil respiratoire et du médiastin Tumors of the respiratory system and mediastinum Appareil respiratoire pathologie Respiratory disease Aparato respiratorio patología Bronche pathologie Bronchus disease Bronquio patología Poumon pathologie Lung disease Pulmón patología Tumeur maligne Malignant tumor Tumor maligno Carcinome non petite cellule bronchopulmonaire non-small cell lung carcinoma Carcinoma no pequeňa célula bronchopulmonar Carcinome non petite cellule Non small cell carcinoma Carcinoma no pequeña célula Carcinome épidermoïde Squamous cell carcinoma Carcinoma epidermoide Cellule tumorale Tumor cell Célula tumoral Etude comparative Comparative study Estudio comparativo Perte hétérozygotie Loss of heterozygosity Pérdida heterozigosis Cancer du poumon Lung cancer Cáncer del pulmón Loss of heterozygosity (LOH) Microsatellite instability (MSI) Microsatellite marker Non-small cell lung cancer Smoking habit
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan ; Pathological Research Laboratory, National Kyushu Cancer Center, 3-1-1 Notame, Fukuoka 811-1395, Japan Rights: Copyright 2005 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pulmonology

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