Epstein-barr virus infection of monocytoid b-cell proliferates : An early feature of primary viral infection?
In: The American journal of surgical pathology, Jg. 29 (2005), Heft 5, S. 595-601
Online
academicJournal
- print, 21 ref
Zugriff:
Monocytoid cells are a subset of B lyniphocytes with characteristic morphology and immunophenotype, which proliferate in a broad variety of reactive lymph node conditions. Up to now, no direct infection of these cells by a pathogenic organism has been identified. We found in a series of lymph node specimens from 13 patients having in common a prominent monocytoid B (MCB)-cell reaction in the absence of epithelioid cells or necrosis evidence that Epstein-Barr virus (EBV) can infect MCB cells. Clinical and serologic findings indicative for an acute EBV infection were reported only in 2 cases. By in situ hybridization and immunohistology, a number of MCB cells in all cases was found to contain EBV-encoded small nuclear RNAs and to express the EBV-encoded nuclear antigen (EBNA)-2 and, in lesser extent, the latent membrane protein-1. EBV-transcripts and proteins were also detectable in a number of extra-follicular B blasts and germinal center B cells in 10 of 13 cases. Our findings imply that an EBV infection of MCB cells associated with predominant EBNA-2 expression represents an early s.ign of primary infection and that it should be included in the different al diagnosis of activated lymph nodes with prominent MCB-cell reaction in the absence of epithelioid cells.
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Epstein-barr virus infection of monocytoid b-cell proliferates : An early feature of primary viral infection?
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Autor/in / Beteiligte Person: | ANAGNOSTOPOULOS, Ioannis ; HUMMEL, Michael ; FALINI, Brunangelo ; JOEHRENS, Korinna ; STEIN, Harald |
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Zeitschrift: | The American journal of surgical pathology, Jg. 29 (2005), Heft 5, S. 595-601 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 21 ref |
ISSN: | 0147-5185 (print) |
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