Cytomegalovirus and human herpesvirus 8 DNA detection in peripheral blood monocytic cells of AIDS patients : Correlations with the presence of Kaposi's sarcoma and CMV disease

VAN DER KUYL, Antoinette C ; POLSTRA, Abeltje M ; et al.

In: Journal of medical virology, Jg. 76 (2005), Heft 4, S. 541-546

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To establish the effect of the presence in blood cells of cytomegalovirus (CMV) and human herpesvirus 8 (HHV8) DNA, two herpesviruses that are activated frequently in AIDS patients, were selected from the Amsterdam Cohort Studies on HIV/AIDS 181 PBMC samples from patients with and without Kaposi's sarcoma (KS), and with and without CMV-related disease. The viral loads of both HHV8 and CMV were determined by real-time PCR at the time of diagnosis of AIDS. There was no significant difference in prevalence and load for CMV between the KS and non-KS patients. The variable related most strongly to KS was the presence of HHV8 DNA in PBMCs, whilst CMV DNA was related to the development of CMV disease and shortened survival. The frequency of detection of HHV8 increased when the patient presented with more severe KS symptoms at diagnosis, but detection of HHV8 DNA did not influence survival. Therefore, HHV8 and CMV DNA measured in the blood of AIDS patients, are each related mainly to the associated disease, and have no additional predictive value in these patients.

Titel:	Cytomegalovirus and human herpesvirus 8 DNA detection in peripheral blood monocytic cells of AIDS patients : Correlations with the presence of Kaposi's sarcoma and CMV disease
Autor/in / Beteiligte Person:	VAN DER KUYL, Antoinette C ; POLSTRA, Abeltje M ; VAN DEN BURG, Remco ; WEVERLING, Gerrit Jan ; GOUDSMIT, Jaap ; CORNELISSEN, Marion
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Journal of medical virology, Jg. 76 (2005), Heft 4, S. 541-546
Veröffentlichung:	New York, NY: Wiley-Liss, 2005
Medientyp:	academicJournal
Umfang:	print, 30 ref
ISSN:	0146-6615 (print)
Schlagwort:	Microbiology, infectious diseases Microbiologie, maladies infectieuses Tropical medicine Médecine tropicale Virology Virologie Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Microbiologie Microbiology Divers Miscellaneous Sciences medicales Medical sciences Tumeurs Tumors Pathologie infectieuse Infectious diseases Viroses Viral diseases Viroses humaines Human viral diseases Viroses du tissu lymphoïde et du sang. Sida Viral diseases of the lymphoid tissue and the blood. Aids Betaherpesvirinae Gammaherpesvirinae Herpesviridae Immunodéficit Immune deficiency Inmunodeficiencia Immunopathologie Immunopathology Inmunopatología Infection Infección Peau pathologie Skin disease Piel patología Tumeur maligne Malignant tumor Tumor maligno Virose Viral disease Virosis Virus Cellule sanguine Blood cell Célula sanguínea Circulation sanguine periphérique Peripheral blood circulation Circulación sanguínea periférica Cytomegalovirus humain Human cytomegalovirus Détection Detection Detección Herpesvirus hominis 8 Human herpesvirus 8 Homme Human Hombre Monocyte Monocito Réaction chaîne polymérase Polymerase chain reaction Reacción cadena polimerasa SIDA AIDS Sarcome Kaposi Kaposi sarcoma Sarcoma Kaposi Temps réel Real time Tiempo real AIDS-KS CMV DNA load HHV8 real-time PCR
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands ; Crucell Holland B.V, Leiden, Netherlands ; Center for Poverty-related Communicable Diseases, Amsterdam, Netherlands Rights: Copyright 2006 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Infectious pathology ; Microbiology ; Tumours

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