PLGA-(L-asp-alt-diol)x-PLGAs with different contents of pendant amino groups : Synthesis and characterization
In: Macromolecular bioscience (Print), Jg. 5 (2005), Heft 7, S. 636-643
Online
academicJournal
- print, 23 ref
Zugriff:
A series of novel biodegdable multi-block copolymers PLGA-(L-Asp-alt-diol)x-PLGA with pendant amino groups was synthesized by ring-opening polymerization of D,L-lactide/glycolide(D,L-LA/GA) (75/25) using poly(N-Chz-L-Asp-alt-diol)s as macroinitiator and stannous octoate as catalyst, in which the N-Cbz-L-Asp represents N-carbobenzyloxy-L-aspartic acid and diols are ethylene glycol, triethylene glycol, PEG200, and PEG600, respectively. Their structures and properties were characterized by FTIR, H NMR, DSC, GPC, ad elemental analysis (EA). The contents of the L-Asp unit in the copolymers were increased from 12.9 to 79.3 mmol . g-1 with decreasing the chain length of the diol, while the glass transition temperatures of the copolymers were decreased from 27.1 to 11.7 °C with increasing the chain length of the diol. Thus, the results in this study provide a way to prepare biomaterials with different L-Asp unit densitie or different number of bioactive sites as well as different properties through adjusting the chain length of the diol.
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PLGA-(L-asp-alt-diol)x-PLGAs with different contents of pendant amino groups : Synthesis and characterization
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| Autor/in / Beteiligte Person: | JIE, ZHAO ; DAPING, QUAN ; KAIRONG, LIAO ; QING, WU |
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| Zeitschrift: | Macromolecular bioscience (Print), Jg. 5 (2005), Heft 7, S. 636-643 |
| Veröffentlichung: | Weinheim: Wiley-VCH, 2005 |
| Medientyp: | academicJournal |
| Umfang: | print, 23 ref |
| ISSN: | 1616-5187 (print) |
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