Individual changes in lamotrigine plasma concentrations during pregnancy
In: Epilepsy research, Jg. 65 (2005), Heft 3, S. 185-188
academicJournal
- print, 8 ref
Zugriff:
Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p = 0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokineti changes display marked inter-patient variation. which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
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Individual changes in lamotrigine plasma concentrations during pregnancy
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Autor/in / Beteiligte Person: | PETRENAITE, Vaiva ; SABERS, Anne ; HANSEN-SCHWARTZ, Jacob |
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Zeitschrift: | Epilepsy research, Jg. 65 (2005), Heft 3, S. 185-188 |
Veröffentlichung: | Amsterdam: Elsevier, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 8 ref |
ISSN: | 0920-1211 (print) |
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