Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype
In: Prenatal diagnosis, Jg. 25 (2005), Heft 11, S. 1048-1056
Online
academicJournal
- print, 26 ref
Zugriff:
Objectives The aim was to report an unusual trizygotic pregnancy that resulted in live-born twins. The placenta of one twin had placental mesenchymal dysplasia (PMD), which resulted from a chimeric fusion of an androgenetic zygote and a normal biparental zygote. The literature review was summarized. Methods The case was first detected hy prenatal ultrasound, and was then followed by a histologic and detailed genetic investigation. The literature on PMD, complete hydatidiform moles (CHMs), and placental mosaicism and chimerism was also reviewed. Results One placenta of a twin pregnancy was noted to be diffusely cystic and enlarged. The macroscopic and microscopic findings were consistent with the diagnosis of PMD; however, genetic findings confirmed confined placental chimerism involving a normal biparental 46,XY male conceptus and an androgenetic 46,XX complete hydatidiform mole. Conclusions This case represents a rare placental abnormality, PMD, which may have a diverse etiology. Therefore, detailed histologic and genetic analysis were performed for an accurate diagnosis.
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Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype
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Autor/in / Beteiligte Person: | SURTI, Urvashi ; HILL, Lyndon M ; DUNN, Jeanette ; PROSEN, Tracy ; HOFFNER, Lori |
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Zeitschrift: | Prenatal diagnosis, Jg. 25 (2005), Heft 11, S. 1048-1056 |
Veröffentlichung: | Chichester: Wiley, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 26 ref |
ISSN: | 0197-3851 (print) |
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