Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males
In: QJM (Oxford. 1994. Print), Jg. 98 (2005), Heft 12, S. 857-863
Online
academicJournal
- print, 15 ref
Zugriff:
Background: Lactose malabsorption (LM) may be associated with reduced skeletal calcium content. Diagnosis to date has been based on indirect methods, with a high false-negative rate. Identification of the LCT polymorphism led to development of a PCR-based test. Aim: To evaluate the PCR-based test compared to a combination the hydrogen breath test and the lactose tolerance test, and investigate anthropometrical differences, changes in bone mineral density and oral calcium intake according to LCT polymorphism and milk-drinking habits. Methods: All participants (n=278) underwent clinical examination, with measurement of height, weight and bone density (DXA), and were genotyped for LCT polymorphism (LCT CC or LCT TT: CC is associated with LM). A subgroup (n=51) had a hydrogen breath test and a lactose tolerance test, in addition to genotyping. Results: Detection of LM by LCT polymorphism was highly significant (p=0.001). The correlation between LCT genotype and self-reported milk-intolerance or dislike of milk with was slight, but the correlation with functional tests was highly significant. Non-milk-drinkers were lighter (-5 kg) and significantly shorter (-4cm) than milk-drinkers (p=0.07 and 0.04, respectively). Total calcium consumption was lower among non-milk-drinkers by about 18% (p=0.03). Discussion: Genotyping is an economic, quick and convenient method for diagnosing lactose malabsorption, with results comparable to existing tests. Sufficient calcium consumption may be relevant to body growth, as milk-drinkers were taller. Negative calcium bone balance may be prevented when provision is made for adequate calcium intake.
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Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males
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Autor/in / Beteiligte Person: | GUGATSCHKA, M ; DOBNIG, H ; FAHRLEITNER-PAMMER, A ; PIETSCHMANN, P ; KUDLACEK, S ; STRELE, A ; OBERMAYER-PIETSCH, B |
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Zeitschrift: | QJM (Oxford. 1994. Print), Jg. 98 (2005), Heft 12, S. 857-863 |
Veröffentlichung: | Oxford: Oxford University Press, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 15 ref |
ISSN: | 1460-2725 (print) |
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