Genetic analysis of regulatory, promoter, and TAR regions of LTR sequences belonging to HIV type 1 non-B subtypes
In: AIDS research and human retroviruses, Jg. 21 (2005), Heft 11, S. 949-954
academicJournal
- print, 14 ref
Zugriff:
Transcriptional activation of HIV-1 gene expression is controlled by the interaction of sequence-specific transcription factors with the long terminal repeat (LTR). Information about differences between LTR regions in distinct HIV-1 subtypes is scarce. LTR sequences, including regulatory, enhancer, promoter, and TAR regions, were genetically characterized and compared in 59 HIV-1-infected individuals known to be infected with non-B subtypes. Phylogenetic analyses ascribed the LTR regions to the following subtypes: 10A, 2B, 6C, 1D, 2E, 2F, 16G, 3J, 2H, and 2U. Up to 34% of the samples were LTR/PR recombinants. The LTR region revealed a high degree of genetic variability among distinct HIV-1 subtypes and showed several subtype-specific markers, which hypothetically could influence the interactions with cellular transcription factors, leading to different transcriptional levels among distinct HIV-1 clades. To our knowledge, this is the first characterization of LTR sequences belonging to subtypes J and H.
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Genetic analysis of regulatory, promoter, and TAR regions of LTR sequences belonging to HIV type 1 non-B subtypes
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Autor/in / Beteiligte Person: | RAMIREZ DE ARELLANO, Eva ; SORIANO, Vincent ; HOLGUIN, Africa |
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Zeitschrift: | AIDS research and human retroviruses, Jg. 21 (2005), Heft 11, S. 949-954 |
Veröffentlichung: | Larchmont, NY: Liebert, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 14 ref |
ISSN: | 0889-2229 (print) |
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