A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus
In: Atherosclerosis, Jg. 184 (2006), Heft 2, S. 404-412
academicJournal
- print, 37 ref
Zugriff:
Introduction: Glutathione S transferases (GST) are enzymes responsible for the metabolism of numerous xenobiotics and play a major cellular antioxidant role. Our aim was firstly, to examine the association between the GSTM1/GST mu-1 (GSTM 1) and GST T1/GST theta-1 (GSTT 1) gene variants with markers of oxidative stress and inflammation in diabetic patients, and secondly to examine the association and potential interaction between these variants and cigarette smoking. Methods: Seven hundred and seventy-three Caucasian subjects with diabetes and 2592 Caucasian non-diabetic subjects were successfully genotyped. Plasma total antioxidant status, C-reactive protein (CRP), oxidized-LDL (Ox-LDL) and LDL-mean/peak particle diameter were recorded in the diabetes sample. Results: No association was seen between genotype and cardiovascular disease (CVD) risk. In the diabetic subjects, GSTT1-1 compared to GSTT1-0 subjects had significantly higher CRP (p=0.001), Ox-LDL (p=0.004) and smaller LDL particles (p=0.01). In subjects without CVD, there was a significant interaction between the GSTT1-1 variant and smoking in determining Ox-LDL (p=0.04). Furthermore, CVD risk was higher in smokers compared to non-smokers with GSTT1-1. No significant associations were observed by GSTM1. Within the non-diabetic sample, no association was observed between genotype and prospective coronary heart disease (CHD) risk. Of note, the frequency of the GSTT1-1 variant was significantly lower in the diabetes subjects compared to the non-diabetic sample (p = 0.01). Conclusions: This study demonstrates an association between the GSTT1-1 variant and markers of inflammation and lipid peroxidation. Furthermore this variant interacts with smoking to increase lipid peroxidation.
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A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus
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Autor/in / Beteiligte Person: | HAYEK, Tony ; STEPHENS, Jeffrey W ; HUBBART, Christina S ; ACHARYA, Jayshree ; CASLAKE, Muriel J ; HAWE, Emma ; MILLER, George J ; HUREL, Steven J ; HUMPHRIES, Steve E |
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Zeitschrift: | Atherosclerosis, Jg. 184 (2006), Heft 2, S. 404-412 |
Veröffentlichung: | Amsterdam: Elsevier, 2006 |
Medientyp: | academicJournal |
Umfang: | print, 37 ref |
ISSN: | 0021-9150 (print) |
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