Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus
In: Experimental brain research, Jg. 168 (2006), Heft 1-2, S. 277-280
Online
academicJournal
- print, 20 ref
Zugriff:
In Parkinson's disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson's disease (PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions.
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Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus
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Autor/in / Beteiligte Person: | STEFANI, Alessandro ; GALATI, Salvatore ; PEPPE, Antonella ; BASSI, Andrea ; PIERANTOZZI, Mariangela ; HAINSWORTH, Atticus H ; BERNARDI, Giorgio ; ORLACCHIO, Antonio ; STANZIONE, Paolo ; MAZZONE, Paolo |
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Zeitschrift: | Experimental brain research, Jg. 168 (2006), Heft 1-2, S. 277-280 |
Veröffentlichung: | Berlin: Springer, 2006 |
Medientyp: | academicJournal |
Umfang: | print, 20 ref |
ISSN: | 0014-4819 (print) |
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