Follow-up of infants given measles vaccine at 6 months of age : antibody and CMI responses to MMRII® at 15 months of age and antibody levels at 27 months of age
In: Vaccine, Jg. 23 (2005), Heft 25, S. 3247-3255
academicJournal
- print, 39 ref
Zugriff:
The worldwide elimination of measles is an important target. In developed countries, to control measles outbreaks, immunization from 6 months of age is recommended. In this study, infants (n=290) who were (1) born to mothers with natural immunity or to vaccinated mothers and (2) previously immunized with Connaught (CLL) or AIK-C measles vaccine at 6 months of age, were evaluated for measles immunity before and after measles-mumps-rubella (MMRII®) at 15 months of age. Eight weeks after MMRII®, 98.9% of infants were seropositive by enzyme immunoassay (EIA) and 70% demonstrated measles specific cellular immunity by blast transformation (BT) of lymphocytes. At 27 months of age, 98.4% of infants had protective antibody levels by plaque reduction neutralization (PRN) test. These results suggest that AIK-C and CLL vaccines elicit durable protective immunity in young infants when used in early immunization programs.
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Follow-up of infants given measles vaccine at 6 months of age : antibody and CMI responses to MMRII® at 15 months of age and antibody levels at 27 months of age
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Autor/in / Beteiligte Person: | CARSON, Mary M ; SPADY, Donald W ; BEELER, Judith A ; KREZOLEK, Margaret P ; AUDET, Susette ; PABST, Henry F |
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Zeitschrift: | Vaccine, Jg. 23 (2005), Heft 25, S. 3247-3255 |
Veröffentlichung: | Oxford: Elsevier, 2005 |
Medientyp: | academicJournal |
Umfang: | print, 39 ref |
ISSN: | 0264-410X (print) |
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