Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
In: Journal of medical virology, Jg. 78 (2006), Heft 9, S. 1147-1157
Online
academicJournal
- print, 1 p.1/2
Zugriff:
Recent studies indicate that a defective proliferative response of HIV-specific CD8+ T cells is associated with the lack of virologic control in chronic HIV infection in humans. The possible mechanisms that might be responsible for the reduced proliferative potential of HIV-specific CD8+ T cells and conditions conducive to the proliferation of CD8+ T cells were examined in 14 HIV-infected individuals and 7 HIV-uninfected controls using CFSE labeling and flow cytometry techniques, and analyzed data using 2 quantitative measurements: the percentages of proliferating CD8+ T cells (Tp), and the maximum number of cell divisions (Dm) after stimulation. It was found that CD8+ T cells from HIV-infected and -uninfected subjects proliferated equally well after polyclonal stimulation by phylohemagglutinin A (PHA); both groups reached a Tp of 92%-96% and a Dm of 5-8. However, in HIV-infected subjects, proliferation of HIV- and CMV-specific CD8+ T cells was significantly reduced compared to proliferation of CMV-specific CD8+ T cells from HIV-uninfected subjects. These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies invivo.
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Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
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Autor/in / Beteiligte Person: | JIE, YU ; HUIYUAN, CHEN ; HORTON, Helen ; BANSAL, Anju ; MCELRATH, Julie M ; REICHMAN, Richard ; GOEPFERT, Paul ; XIA, JIN |
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Zeitschrift: | Journal of medical virology, Jg. 78 (2006), Heft 9, S. 1147-1157 |
Veröffentlichung: | New York, NY: Wiley-Liss, 2006 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/2 |
ISSN: | 0146-6615 (print) |
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