Lignan and isoflavone excretion in relation to uterine fibroids : a case-control study of young to middle-aged women in the United States
In: The American journal of clinical nutrition, Jg. 84 (2006), Heft 3, S. 587-593
Online
academicJournal
- print, 55 ref
Zugriff:
Background: Uterine fibroids are hormonally responsive; estradiol and progesterone stimulate their growth, and gonadotrophin-releasing hormone agonists shrink them. Phytoestrogens, including isoflavones and lignans, can act as weak estrogens or antiestrogens. Objective: The objective of this case-control study was to evaluate the relation between uterine fibroid risk and phytoestrogen exposure. Design: Two overnight urine collections (48 h apart) from 170 uterine fibroid cases and 173 controls were analyzed for isoflavonoids (ie, daidzein, genistein, equol, and 0-desmethylangolensin) and lignans (enterodiol and enterolactone). Logistic regression was used to determine associations between the mean excretion of the 2 collections and the risk of uterine fibroids. Results: Unadjusted isoflavone excretion did not differ significantly between cases and controls (2.33 ± 5.82 and 2.60 ± 5.90 nmol/mg Cr, respectively; P = 0.68), but cases excreted significantly less lignans than did controls (2.86 ± 3.45 and 4.57 ± 6.67 nmol/mg Cr, respectively; P < 0.01). The trend for a reduced risk of uterine fibroids with increasing quartiles of lignan excretion was significant (odds ratio for highest versus lowest quartile = 0.31; 95% CI: 0.17, 0.58; P for trend < 0.01). When adjusted for age, BMI, race, family history of uterine fibroids, and isoflavone excretion, this trend remained but was attenuated (P = 0.07). Conclusions: Our findings suggest a modest inverse association between lignan excretion and uterine fibroid risk. Whether this relation represents an effect of lignans per se or of other constituents of lignan-containing foods on the development of uterine fibroids remains to be determined. No association was found between isoflavone excretion and uterine fibroids; however, the intake of soy foods, the primary source of isoflavones, was low in this population.
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Lignan and isoflavone excretion in relation to uterine fibroids : a case-control study of young to middle-aged women in the United States
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Autor/in / Beteiligte Person: | ATKINSON, Charlotte ; LAMPE, Johanna W ; SCHOLES, Delia ; CHU, CHEN ; WÄHÄLÄ, Kristiina ; SCHWARTZ, Stephen M |
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Zeitschrift: | The American journal of clinical nutrition, Jg. 84 (2006), Heft 3, S. 587-593 |
Veröffentlichung: | Bethesda, MD: American Society for Clinical Nutrition, 2006 |
Medientyp: | academicJournal |
Umfang: | print, 55 ref |
ISSN: | 0002-9165 (print) |
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