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Objective: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulin-like growth factor-1 (IGF-I), and its binding protein (IGFBP)-3. Design: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. Results: Adjusted mean serum IGF-I values were lower in women with BMI <22.5 kg/m2 or BMI >29.2 kg/m2 compared to women with BMI within this range (Pheterogeneity< 0.0001, Ptrend = 0.35). Insulin-like growth factor-1 was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (Ptrend = 0.005). Conclusions: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.

Titel:	Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women
Autor/in / Beteiligte Person:	GRAM, I. T ; NORAT, T ; BUENO-DE-MESQUITA, H. B ; NAGEL, G ; LINSEISEN, J ; LAHMANN, P. H ; BOEING, H ; PALLI, D ; SACERDOTE, C ; PANICO, S ; TUMINO, R ; SIERI, S ; RINALDI, S ; DORRONSORO, M ; QUIROS, J. R ; NAVARRO, C. A ; BARRICARTE, A ; TORMO, M.-J ; GONZALEZ, C. A ; OVERVAD, K ; PAASKE JOHNSEN, S ; OLSEN, A ; TJØNNELAND, A ; DOSSUS, L ; TRAVIS, R ; ALLEN, N ; BINGHAM, S ; KHAW, K.-T ; STATTIN, P ; TRICHOPOULOU, A ; KALAPOTHAKI, V ; PSALTOPOULOU, T ; CASAGRANDE, C ; RIBOLI, E ; LUKANOVA, A ; KAAKS, R ; TEHARD, B ; CLAVEL-CHAPELON, F ; VAN GILS, C. H ; VAN NOORD, P. A. H ; PEETERS, P. H. M
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	International journal of obesity, Jg. 30 (2006), Heft 11, S. 1623-1631
Veröffentlichung:	Basingstoke: Nature Publishing, 2006
Medientyp:	academicJournal
Umfang:	print, 58 ref
ISSN:	0307-0565 (print)
Schlagwort:	Europe Europa Nutrition, obesity, metabolic disorders Nutrition, obésité, maladies métaboliques Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Vertebres: anatomie et physiologie, organisme dans son ensemble ou etude de plusieurs organes ou systemes Vertebrates: anatomy and physiology, studies on body, several organs or systems Alimentation. Comportement alimentaire Feeding. Feeding behavior Sciences medicales Medical sciences Maladies metaboliques Metabolic diseases Obésité Obesity Sante publique. Hygiene-medecine du travail Public health. Hygiene-occupational medicine Santé publique. Hygiène Public health. Hygiene Divers Miscellaneous Trouble nutrition Nutrition disorder Trastorno nutricíon Etat nutritionnel Nutritional status Estado nutricional Européen European Europeo Facteur croissance IGF1 Insulin like growth factor 1 Factor crecimiento IGF1 Femelle Female Hembra Femme Woman Mujer Homme Human Hombre Indice masse corporelle Body mass index Indice masa corporal Liquide biologique Biological fluid Líquido biológico Métabolisme pathologie Metabolismo patología Nutrition Nutrición Obesidad Rapport taille-hanche Waist hip ratio Relación cintura cadera Santé publique Public health Salud pública Sérum Serum Suero Protéine liaison IGFBP3 Insulin-like growth factor binding protein-3 Proteína enlace IGFBP3 Tour de taille Waist circumference IGF-I IGFBP-3 body mass index waist-hip ratio women Subject Geographic: Europe Europa
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Institute of Community Medicine, School of Medicine, University of Tromsø, Tromsø, Norway ; International Agency for Research on Cancer, Lyon, France ; Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands ; Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany ; Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany ; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Centre, Scientific Institute of Tuscany, Florence, Italy ; CPO-Piemonte, Torino, Italy ; Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy ; Cancer Registry, Azienda Ospedaliera 'Civile M.P. Arezzo', Ragusa, Italy ; Ejidemiology Unit, Istituto Tumori, Milan, Italy ; Subdirecci6n de Salud Pública de Gipuzkoa, San Sebastian, Spain ; Sección Información Sanitaria, Consejeía de Salud y Servicios Sanitarios de Asturias, Asturias, Spain ; Consejería de Sanidad y Consumo, Murcia, Spain ; Public Health Institute of Navarra, Oxford, Spain ; Departrrent of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain ; Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark ; Departrrent of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark ; Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark ; Epidemiology Unit, Cancer Research UK, University of Oxford, Pamplong, United Kingdom ; MRC Dunn Nutrition Unit, Cambridge, United Kingdom ; Institute of Public Health, University of Cambridge, Cambridge, United Kingdom ; University of UmeÅ, UMEÅ, Sweden ; New York University School of Medicine, New York, United States ; Institut National de la Santé et de la Recherche Médicalé (INSERM) U521, Institut Gustave Roussy, Vilkjuif, France ; fulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands Rights: Copyright 2006 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Metabolic diseases ; Public health. Hygiene-occupational medicine. Information processing ; Vertebrates : anatomy and physiology, studies on body, several organs or systems

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Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women