Differential diagnosis between Complete and partial mole using a TSSC3 antibody: Correlation with DNA polymorphic marker analysis

KATO, Hidenori ; WAKE, Norio

In: Advances in the management of gestational trophoblastic diseaseJournal of reproductive medicine 51(11):861-867; Jg. 51 (2006) 11, S. 861-867

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OBJECTIVE: To investigate the use of maternally expressed, imprinted genes for the differential diagnosis of complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM). STUDY DESIGN: Expression patterns of imprinted genes in CHM were validated by microarray analysis. Twenty CHMs and 10 PHMs were then subjected to Western blot analysis and immunostaining with appropriate antibodies. RESULTS: TSSC3 (also known as PHLDA2, IPL), SLC22A1L, KCNQ1 and decorin were shown to be down-regulated, with the suppression of TSSC3 most marked. In all 20 CHM cases for which the diagnosis had been confirmed by DNA polymorphic markers, the expression of TSSC3 was completely lost on Western blots. In contrast, in 10 PHMs that had also been diagnosed by DNA analysis, TSSC3 was expressed normally. Immunohistochemistry showed an identical result. CONCLUSION: Complete silencing of TSSC3 expression in CHM offers a convenient and novel diagnostic strategy for diagnosing molar lesions.

Titel:	Differential diagnosis between Complete and partial mole using a TSSC3 antibody: Correlation with DNA polymorphic marker analysis
Autor/in / Beteiligte Person:	KATO, Hidenori ; WAKE, Norio
Link:	View record from PASCAL Archive
Quelle:	Advances in the management of gestational trophoblastic diseaseJournal of reproductive medicine 51(11):861-867; Jg. 51 (2006) 11, S. 861-867
Veröffentlichung:	Saint-Louis, MO: Science, 2006
Medientyp:	Konferenz
Umfang:	print, 24 ref
ISSN:	0024-7758 (print)
Schlagwort:	Endocrinology Endocrinologie Obstetrics, gynecology, andrology Gynécologie, obstétrique, andrologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Gynecologie. Andrologie. Obstetrique Gynecology. Andrology. Obstetrics Gestation. Foetus. Placenta Pregnancy. Fetus. Placenta Pathologie mère, foetus, gestation Diseases of mother, fetus and pregnancy Gestation pathologie Pregnancy disorders Gestación patología Placenta pathologie Placenta diseases Placenta patología Trophoblaste pathologie Trophoblaste pathology Trofoblasto patología Tumeur Tumor Analyse corrélation Correlation analysis Análisis correlación Anticorps Antibody Anticuerpo Diagnostic différentiel Differential diagnostic Diagnóstico diferencial Gynécologie Gynecology Ginecología Marqueur génétique Genetic marker Marcador genético Mole hydatiforme Hydatidiform mole Mola hidatiforme Obstétrique Obstetrics Obstétrico Partiel Partial Parcial Polymorphisme Polymorphism Polimorfismo Gène IPL
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Conference Paper File Description: text Language: English Author Affiliations: Department of Gynecology, National Hokkaido Cancer Center, Sapporo City, Department of Reproductive and Developmental Medicine, Faculty of Medical Sciences, Medical School, Kyushu University, Fukuoka City, Japan Rights: Copyright 2007 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Gynecology. Andrology. Obstetrics

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