A placebo-controlled comparison of the efficiency of triple-and monotherapy in category III B chronic pelvic pain syndrome (CPPS). Commentary
In: European urology, Jg. 51 (2007), Heft 4, S. 1113-1118
academicJournal
- print, 31 ref
Zugriff:
Objectives: To perform a prospective, placebo-controlled study to examine the efficacy of α-blocker compared with triple therapy (a-blocker, anti-inflammatory, and muscle relaxant) in the treatment of Category IIIB chronic pelvic pain syndrome (Category IIIB CPPS). Materials and methods: The study was conducted between September 2004 and December 2005, and included 90 treatment naive patients, aged 22-42 yr (mean age: 29.1 ± 5.2) with Category IIIB CPPS, who were randomized into three groups: group 1, Α-blocker; group 2, combination of α-blocker, anti-inflammatory, and muscle relaxant; group 3, placebo once daily. The patients were treated for 6 mo and were followed up for a further 6 mo. Changes from baseline in the total and domain scores of the NIH Chronic Prostatitis Symptom Index (NIH-CPSI) were evaluated. The primary criterion for response was scoring <2 on the NIH-CPSI quality of life item. The secondary criterion for response was >50% reduction in NIH-CPSI pain score. Results: The NIH-CPSI initial and sixth-month total scores were 23.1 and 10.7, respectively, in group 1, and 21.9 and 9.2, respectively, in group 2. The initial and sixth-month scores remained stable in group 3 (22.9 and 21.9, respectively). There was no statistically significant difference between two treatment arms with respect to efficiency of treatment (p > 0.05). The responses in groups 1 and 2 were found durable at the end of 12 mo. Conclusions: We found that α-blocker monotherapy was as effective and safe as triple therapy in the treatment of Category IIIB CPPS.
Titel: |
A placebo-controlled comparison of the efficiency of triple-and monotherapy in category III B chronic pelvic pain syndrome (CPPS). Commentary
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Autor/in / Beteiligte Person: | TUGCU, Volkan ; ALI IHSAN, TAQ ; FAZHOGLU, Adem ; GÜRBÜZ, Gökhan ; OZBEK, Emin ; SAHIN, Secluk ; KURTULUS, Fatih ; CEK, Mete ; CORMIO, Luigi |
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Zeitschrift: | European urology, Jg. 51 (2007), Heft 4, S. 1113-1118 |
Veröffentlichung: | Oxford: Elsevier, 2007 |
Medientyp: | academicJournal |
Umfang: | print, 31 ref |
ISSN: | 0302-2838 (print) |
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