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Evidence supports an important role for β-amyloid (Aβ) in the pathogenesis of Alzheimer's disease (AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long Aβ peptides (Aβ40 and Aβ42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4-6 years of follow-up time. CSF Aβ42 concentration at baseline and the Aβ42/Aβ40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia (p < 0.001). The baseline levels of Aβ40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The Aβ42/Aβ40 ratio was superior to Aβ42 concentration with regard to identifying incipient AD in MCI (p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Aβ42/ Aβ40 ratio as a predictive biomarker for AD.

Titel:	Prediction of Alzheimer's disease using the CSF Aβ42/Aβ40 ratio in patients with mild cognitive impairment
Autor/in / Beteiligte Person:	HANSSON, Oskar ; ZETTERBERG, Henrik ; BUCHHAVE, Peder ; ANDREASSON, Ulf ; LONDOS, Elisabet ; MINTHON, Lennart ; BLENNOW, Kaj
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Dementia and geriatric cognitive disorders, Jg. 23 (2007), Heft 5, S. 316-320
Veröffentlichung:	Basel: Karger, 2007
Medientyp:	academicJournal
Umfang:	print, 24 ref
ISSN:	1420-8008 (print)
Schlagwort:	Gerontology geriatrics Gérontologie Neurology Neurologie Psychology, psychopathology, psychiatry Psychologie, psychopathologie, psychiatrie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Neuropharmacologie Neuropharmacology Psychoanaleptiques: stimulant snc, antidépresseur, nootrope, normothymique..., (maladie d'alzheimer) Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Maladies dégénératives et hérédodégénératives du système nerveux. Leucodystrophies. Maladies à prions Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Anesthesie. Reanimation. Transfusion. Therapie cellulaire et therapie genique Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Réanimation. Soins intensifs Intensive care medicine Réanimation de la fonction cardiocirculatoire. Choc cardiogène. Soins intensifs coronaires Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Psychologie. Psychanalyse. Psychiatrie Psychology. Psychoanalysis. Psychiatry Psychopharmacologie Psychopharmacology Encéphale pathologie Cerebral disorder Encéfalo patología Maladie dégénérative Degenerative disease Enfermedad degenerativa Système nerveux central pathologie Central nervous system disease Sistema nervosio central patología Déficit cognitif léger mild cognitive impairment Disturbio cognitivo ligero Démence Alzheimer Alzheimer disease Demencia Alzheimer Démence Dementia Demencia Homme Human Hombre Liquide céphalorachidien Cerebrospinal fluid Líquido cefalorraquídeo Système nerveux pathologie Nervous system diseases Sistema nervioso patología Trouble cognition Cognitive disorder Trastorno cognitivo Alzheimer's disease Amyloid Biomarkers Mild cognitive impairment
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden ; Neuropsychiatric Clinic, Malmö University Hospital, Malmö, Sweden ; Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden ; Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden Rights: Copyright 2007 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy ; Neurology ; Pharmacological treatments ; Psychopathology. Psychiatry. Clinical psychology ; FRANCIS

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Prediction of Alzheimer's disease using the CSF Aβ42/Aβ40 ratio in patients with mild cognitive impairment