Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP

CAO, Zi-Peng ; FENG, WANG ; et al.

In: Neuroscience letters, Jg. 418 (2007), Heft 3, S. 217-221

academicJournal - print, 26 ref

Dietary conjugated linoleic acid (CLA) has been investigated for its beneficial effects on disease prevention and treatment, and now obesity is one of the most perspective researching highlights. In a variety of experimental models, the results of studies on the effects of CLA on food intakes are somewhat inconsistent. Our experiment was conducted to extend these observations to hypothalamus and other regions within the central nervous system so that the mechanism of the actions of CLA might be more easily elucidated. In the experiment, a permanent cannula was inserted into the lateral ventricle of each rat. For the experiment, animals received intracerebroventricular injections of either 150nmol (n= 16) CLA, or LA as non-conjugated control, or normal saline as vehicle. Hypothalamus and blood samples were collected at the 2nd, 4th, 8th, and 14th day. The results show that CLA in cerebral ventricle can inhibit food intake of experimented rats and this inhibition is related with the decreased expression of neuropeptides Y (NPY) and agouti-related protein (AgRP). The circulating leptin level was also increased by this tentative treatment (2.94 ±0.71 versus 1.18±0.18ng/ml). However, the glucose metabolism was not affected by ICV CLA. It is concluded that CLA in brain can inhibit the appetite of rats through the mechanism of decreasing the expression of NPY and AgRP.

Titel:	Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP
Autor/in / Beteiligte Person:	CAO, Zi-Peng ; FENG, WANG ; XIANG, Xue-Song ; RUI, CAO ; ZHANG, Wen-Bin ; GAO, Shuang-Bin
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Neuroscience letters, Jg. 418 (2007), Heft 3, S. 217-221
Veröffentlichung:	Shannon: Elsevier, 2007
Medientyp:	academicJournal
Umfang:	print, 26 ref
ISSN:	0304-3940 (print)
Schlagwort:	Neurology Neurologie Physiology, morphology Physiologie, morphologie Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Vertebres: systeme nerveux et organes des sens Vertebrates: nervous system and sense organs Acide gras insaturé Unsaturated fatty acid Acido graso no saturado Acide gras n-6 n-6 fatty acid Acido graso n-6 Acide gras polyinsaturé Polyunsaturated fatty acid Acido graso poliinsaturado Alimentation Feeding Alimentación Lipide Lipids Lípido Appétit Appetite Apetito Consommation alimentaire Food intake Consumo alimenticio Expression génique Gene expression Expresión genética Linoléique acide Linoleic acid Linoleico ácido Neuropeptide Y Neuropéptido Y Satiété Satiety Saciedad Voie intracérébrale Intracerebral administration Vía intracerebral CLA Neuropeptides
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Nutrition and Food Hygiene, the Fourth Military Medical University, China Rights: Copyright 2007 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Vertebrates : nervous system and sense organs

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