The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies
In: Parasitology research (1987), Jg. 101 (2007), Heft 3, S. 767-774
Online
academicJournal
- print, 1 p.1/4
Zugriff:
Different domains of a novel full-length var gene (termed 732var) isolated from a placenta of a malaria-infected woman were expressed in Escherichia coli as recombinant proteins and analysed biochemically and immunologically. Two of these, the Duffy binding-like (DBL)-3y domain and the cysteine-rich interdomain region (CIDR)-1α were able to bind chondroitin sulfate A and CD36, respectively. The DBL-3y domain was investigated in a previous study and confirmed here to exhibit anti-disease characteristics related to pregnancy-associated malaria. Mothers with high anti-DBL-3y antibody levels were protected from placental infection. The novel finding in this study is that babies born to mothers carrying anti-CIDR-1α antibodies had a delayed time to the first infection.
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The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies
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Autor/in / Beteiligte Person: | KHATTAB, Ayman ; CHIA, Yu-Shan ; MAY, Jürgen ; LE HESRAN, Jean-Yves ; DELORON, Philippe ; KLINKERT, Mo-Quen |
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Zeitschrift: | Parasitology research (1987), Jg. 101 (2007), Heft 3, S. 767-774 |
Veröffentlichung: | Berlin: Springer, 2007 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/4 |
ISSN: | 0932-0113 (print) |
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