CINS is a much less reproducible and less valid diagnosis than CIN3 : Results from a histological review of population-based cervical samples
In: International journal of gynecological pathology, Jg. 26 (2007), Heft 4, S. 441-446
academicJournal
- print, 19 ref
Zugriff:
We wished to compare the relative reproducibility and validity of cervical intraepithelial neoplasia (CIN) 2 and CIN3 diagnoses. In a population-based cohort study (1993-2001) of human papillomavirus (HPV) and cervical neoplasia in Costa Rica, we compared community pathologists' diagnoses with those of the 2 independent reviewers from the United States (total, n = 357). As measures of validity, we correlated primary and review diagnoses with HPV positivity and cytological interpretations. Two review pathologists agreed with 84% and 81%, respectively, of initial diagnoses of CIN3 compared with 13% and 31% of CIN2. The CIN3 diagnoses made by review pathologists were 94% oncogenic HPV positive, compared with 72% of CIN2 diagnoses. Eighty-one percent of CIN3 diagnoses versus 61% of CIN2 were correlated with high-grade cytological interpretations. The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2.
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CINS is a much less reproducible and less valid diagnosis than CIN3 : Results from a histological review of population-based cervical samples
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Autor/in / Beteiligte Person: | CARREON, Joseph D ; SHERMAN, Mark E ; BURK, Robert D ; SCHIFFMAN, Mark ; GUILLEN, Diego ; SOLOMON, Diane ; HERRERO, Rolando ; JERONIMO, Jose ; WACHOLDER, Sholom ; RODRIGUEZ, Ana Cecilia ; MORALES, Jorge ; HUTCHINSON, Martha |
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Zeitschrift: | International journal of gynecological pathology, Jg. 26 (2007), Heft 4, S. 441-446 |
Veröffentlichung: | Hagerstown, MD; Philadelphia, PA: Lippincott, 2007 |
Medientyp: | academicJournal |
Umfang: | print, 19 ref |
ISSN: | 0277-1691 (print) |
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