c-Maf expression in angioimmunoblastic T-cell lymphoma
In: The American journal of surgical pathology, Jg. 31 (2007), Heft 11, S. 1695-1702
Online
academicJournal
- print, 44 ref
Zugriff:
The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated. We previously examined c-Maf expression in various T-cell lymphomas by reverse-transcription polymerase chain reaction and found extremely elevated c-Maf levels in angioimmunoblastic T-cell lymphoma (AILT). In this study, we examined T-cell lymphomas for c-Maf and cyclin expression immunohistochemically. Of 93 cases of T-cell lymphomas we investigated in the current study, c-Maf expression was seen in 23 out of 31 cases of AILT, 3 out of 11 of adult T-cell leukemia/ lymphoma, 4 out of 19 of peripheral T-cell lymphoma, unspecified [PTCL(U)], and 0 out of 11 cases of mycosis fungoides, 0 out of 11 of anaplastic large cell lymphoma, and 1 out of 10 of extranodal NK/T-cell lymphoma, nasal type. Double immunostaining in AILT revealed that the majority of c-Maf-positive cells were also positive for CD43 (MT1), CD45RO (UCHL-1), and CD4 but were negative for CD20 (L26). Additionally, cyclins Dl and D2, which stimulate cell cycle progression, were overexpressed in a large number of the c-Maf-positive AILT samples. Quantitative reverse-transcription polymerase chain reaction analysis also showed that c-Maf was overexpressed in 8/31 cases of AILT, 0/19 cases of PTCL(U), 0/11 cases of anaplastic large cell lymphoma, 0/10 cases of extranodal NK/T-cell lymphoma, nasal type, and 2/8 cases of multiple myeloma, presenting significant difference between AILT and PTCL(U) (P = 0.016, Χ2 test).These findings strongly suggest that CD4-positive neoplastic T cells in AILT show c-Maf expression and provide new insight into the pathogenesis of AILT suggesting c-Maf to be a useful diagnostic marker for AILT.
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c-Maf expression in angioimmunoblastic T-cell lymphoma
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Autor/in / Beteiligte Person: | MURAKAMI, Yoshiko Idate ; YATABE, Yasushi ; MITSUYA, Hiroaki ; IMAGAWA, Shigehiko ; SUZUKI, Atsushi ; ESUMI, Hiroyasu ; SAKAI, Masaharu ; TAKAHASHI, Satoru ; MORI, Naoyoshi ; SAKAGUCHI, Teruhiro ; SASAKI, Eiichi ; YAMASHITA, Yoriko ; MORITO, Naoki ; YOH, Keigyou ; FUJIOKA, Yuuki ; MATSUNO, Fumihiko ; HATA, Hiroyuki |
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Zeitschrift: | The American journal of surgical pathology, Jg. 31 (2007), Heft 11, S. 1695-1702 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2007 |
Medientyp: | academicJournal |
Umfang: | print, 44 ref |
ISSN: | 0147-5185 (print) |
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