Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (complex I) activity in the hypoxic/reoxygenated rat heart
In: Biochemical journal (London. 1984), Jg. 274 (1991), S. 133-137
academicJournal
- print, 23 ref 1
Zugriff:
Reoxygenation of the hypoxic myocardium result in a number of processes, including an O2-dependent increase in total tissue Ca2+ and cell lysis in which mitochondrial electron transport plays a key role. In the present study we have isolated mitochondria from perfused rat hearts subjected to hypoxia and found no change in their respiratory function relative to controls. In contrast, mitochondria isolated immediately after reoxygenation of hypoxic-perfused hearts exhibited a specific and significant decrease in NADH:CoQ reductase (Complex I; EC 1.6.5.3) activity, as measured both polarographically and spectrophotometrically.
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Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (complex I) activity in the hypoxic/reoxygenated rat heart
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Autor/in / Beteiligte Person: | HARDY, L ; CLARK, J. B ; DARLEY-USMAR, V. M ; SMITH, D. R ; STONE, D |
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Zeitschrift: | Biochemical journal (London. 1984), Jg. 274 (1991), S. 133-137 |
Veröffentlichung: | Colchester: Portland Press, 1991 |
Medientyp: | academicJournal |
Umfang: | print, 23 ref 1 |
ISSN: | 0264-6021 (print) |
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