A multivariate analysis of prognostic indicators in complete hydatidiform moles (CHM)
In: European journal of obstetrics, gynecology, and reproductive biology, Jg. 87 (1999), Heft 1, S. 69-75
academicJournal
- print, 18 ref
Zugriff:
Objective: To analyse prognostic factors in complete hydatidiform moles using multiple logistic regression analysis. Methods: Evaluation of host and tumour related parameters including (a) gestational age, patient age, parity, molar phenotype, grade of proliferation of the tumour and cytological atypia, (b) expression of β-HCG, EGF, EGFR, TGF-α, TGF-β, IL1-α, IL1-β by immunohistochemistry, (c) serial monitoring of serum β-HCG levels by ELISA, and (d) lectin binding using jack fruit lectin histochemistry as indices for persisting trophoblastic disease (PTD). Results: Serum β-HCG levels at 4 weeks, cellular atypia, lectin binding, expression of TGF-α and IL1-β showed highly significant correlation with persistence of the tumour (P<0.001). The sensitivity and specificity at 4 weeks in combination with cytological atypia to identify spontaneously regressing lesions was 100% and those requiring chemotherapeutic intervention was 80%. Conclusion: The concentration of serum β-HCG 4 weeks post evacuation(<300 mIU/ml) combined with cytological abnormalities could identify nearly 100% of the spontaneously regressing lesions (low risk) and 80% of those needing chemotherapeutic intervention (high risk), thereby suggesting that patients who have a serum β-HCG at 4 weeks of evacuation <300 mIU/ml with no cytological atypia of the trophoblasts need only be followed up at long intervals, while those having a serum β-HCG at 4 weeks of evacuation >300 mIU/ml accompanied with cytological atypia of the trophoblasts should be closely followed up.
Titel: |
A multivariate analysis of prognostic indicators in complete hydatidiform moles (CHM)
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Autor/in / Beteiligte Person: | BALARARN, P ; JOHN, M ; RAJALEKSHMY, T. N ; MATHEW, A ; ENOSE, S ; GANGADHARAN, V. P |
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Zeitschrift: | European journal of obstetrics, gynecology, and reproductive biology, Jg. 87 (1999), Heft 1, S. 69-75 |
Veröffentlichung: | Shannon: Elsevier, 1999 |
Medientyp: | academicJournal |
Umfang: | print, 18 ref |
ISSN: | 0301-2115 (print) |
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