[18F]Galacto-RGD Positron Emission Tomography for Imaging of αvβ3 Expression on the Neovasculature in Patients with Squamous Cell Carcinoma of the Head and Neck

BEER, Ambros J ; GROSU, Anca-Ligia ; et al.

In: Clinical cancer research, Jg. 13 (2007), Heft 22, S. 6610-6616

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Purpose: [18F] Galacto-RGD has been developed for positron emission tomography (PET)-imaging of αvβ3 expression, a receptor involved in angiogenesis and metastasis. Our aim was to study the feasibility of PET imaging with [18F]Galacto-RGD in patients with squamous cell carcinoma of the head and neck (SCCHN). Experimental Design: Eleven patients with primary diagnosis of SCCHN were examined. After injection of 140 to 200 MBq [18F] Galacto-RGD, static emission scans 60 min post injection from the head to the abdomen (n = 11) and dynamic scans >60 min covering the tumor region (n = 6) for kinetic modeling were acquired. Standardized uptake values (SUV) were measured in tumors, muscle and oral mucosa. Immunohistochemistry was done using an αvβ3-specific antibody (n = 7). Image fusion with magnetic resonance imaging and/or computed tomography (CT) scans (n = 8) and calculation of tumor subvolumes based on SUVs was done using the iPlan software (BrainLAB). Results: [18F]Galacto-RGD PET identified 10 of 12 tumors, with SUVs ranging from 2.2 to 5.8 (mean, 3.4 ± 1.2). Two tumors <5 mm were missed. Tumor/blood and tumor/muscle ratios were 2.8 ± 1.1 and 5.5 ± 1.6, respectively. Tumor kinetics was consistent with a two-tissue compart-mental model with reversible specific binding. Immunohistochemistry confirmed αvβ3 expression in all tumors with avp3 being located on the microvessels in all specimens and additionally on tumor cells in one specimen. Image fusion of [18F]Galacto-RGD PET with magnetic resonance imaging/multislice CTand definition of tumor subvolumes was feasible in all cases. Conclusions: [18F] Galacto-RGD PETallows for specific imaging of αvβ3 expression in SCCHN with good contrast. Image fusion and definition of tumor subvolumes is feasible. This technique might be used for the assessment of angiogenesis and for planning and response evaluation of αvβ3-targeted therapies.

Titel:	[18F]Galacto-RGD Positron Emission Tomography for Imaging of αvβ3 Expression on the Neovasculature in Patients with Squamous Cell Carcinoma of the Head and Neck
Autor/in / Beteiligte Person:	BEER, Ambros J ; GROSU, Anca-Ligia ; CARLSEN, Janette ; KOLK, Andreas ; SARBIA, Mario ; STANGIER, Isabelle ; WATZLOWIK, Petra ; WESTER, Hans-Jürgen ; HAUBNER, Roland ; SCHWAIGER, Markus
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Clinical cancer research, Jg. 13 (2007), Heft 22, S. 6610-6616
Veröffentlichung:	Philadelphia, PA: American Association for Cancer Research, 2007
Medientyp:	academicJournal
Umfang:	print, 34 ref 1
ISSN:	1078-0432 (print)
Schlagwort:	Medical oncology Cancérologie Pharmacology drugs Pharmacologie, galénique Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Anticancéreux Antineoplastic agents Otorhinolaryngologie. Stomatologie Otorhinolaryngology. Stomatology Otorhinolaryngologie (tête cou, généralités et divers) Otorhinolaryngology (head neck, general aspects and miscellaneous) Tumeurs Tumors Cancer Cáncer Exploration radioisotopique Radionuclide study Exploración radioisotópica Pathologie ORL ENT disease ORL patología Tumeur maligne Malignant tumor Tumor maligno Cancer de la tête et du cou Head and neck cancer Cáncer de cabeza y cuello Carcinome épidermoïde de la tête et du cou Head and neck squamous cell carcinoma Carcinoma epidermoideo cabeza cuello Expression génique Gene expression Expresión genética Homme Human Hombre Imagerie médicale Medical imagery Imaginería médica Intégrine αvβ3 αvβ3 Integrin Integrina αvβ3 Protéine CAM Cell adhesion molecule Proteína CAM Tomographie par émission de positons Positron emission tomography Tomografía emisión positrones Tomoscintigraphie Emission tomography Tomocentelleografía
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Nuclear Medicine, Technische Universitat München, Munich, Germany ; Department of Radiation Therapy, Technische Universitat München, Munich, Germany ; Department of Cranio -Maxillofacial Surgery, Technische Universitat München, Munich, Germany ; Department of Pathology, Technische Universitat München, Munich, Germany ; Universitätsklinik für Nuklearmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria Rights: Copyright 2008 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Otorhinolaryngology. Stomatology ; Pharmacological treatments

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