Transcriptional Signals of T-cell and Corticosteroid-sensitive Genes Are Associated With Future Acute Cellular Rejection in Cardiac Allografts
In: The Journal of heart and lung transplantation, Jg. 26 (2007), Heft 12, S. 1255-1263
academicJournal
- print, 26 ref
Zugriff:
Background: Profiling mRNA levels of 11 informative genes expressed by circulating immune effector cells identifies cardiac allograft recipients at low risk for current moderate-severe acute cellular rejection (ACR). Methods: We conducted a nested case-control study of 104 cardiac allograft recipients to investigate the association of transcriptional profiles of blood samples with either a future rejection episode within 12 weeks of a baseline clinical sample or persistent histologic quiescence for the same time period. Results: The transcription profile yielded a score (0 to 40 scale) of 27.4 ± 6.3 for future rejectors (n = 39) and 23.9 ±7.1 for controls (n = 65) (p = 0.01). In patients who were ≤180 days post-transplant, the gene expression score was 28.4 ± 4.9 for rejectors (n = 28) and 22.4 ± 7.5 for controls (n = 48) (p < 0.001). In this period, no samples from patients who went on to reject within 12 weeks had gene expression scores of <20. Differential expression of the gene IL1R2 was significantly associated with future events. Of 33 additional genes profiled, 5 supported corticosteroid-sensitive constituents (IL1R2 and FLT3), whereas 6 supported T-cell activation (PDCD1). Conclusions: These data suggest that pathways regulating T-cell homeostasis and corticosteroid sensitivity are associated with future ACR in cardiac allografts and suggest that these signals are evident before histologically detectable rejection.
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Transcriptional Signals of T-cell and Corticosteroid-sensitive Genes Are Associated With Future Acute Cellular Rejection in Cardiac Allografts
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Autor/in / Beteiligte Person: | MEHRA, Mandeep R ; KOBASHIGAWA, Jon A ; PAULY, Daniel F ; DEDRICK, Russell ; WALKER, Michael G ; ZEEVI, Adriana ; EISEN, Howard J ; DENG, Mario C ; FANG, Kenneth C ; KLINGLER, Tod M ; LAL, Preeti G ; ROSENBERG, Steven ; UBER, Patricia A ; STARLING, Randall C ; MURALI, Srinivas ; Investigators, CARGO |
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Zeitschrift: | The Journal of heart and lung transplantation, Jg. 26 (2007), Heft 12, S. 1255-1263 |
Veröffentlichung: | New York, NY: Elsevier Science, 2007 |
Medientyp: | academicJournal |
Umfang: | print, 26 ref |
ISSN: | 1053-2498 (print) |
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