Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation
In: Blood, Jg. 112 (2008), Heft 8, S. 3082-3087
Online
academicJournal
- print, 16 ref
Zugriff:
Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term outcomes and identify clinical predictors of outcome in patients with advanced-stage disease (ASD, n = 92) and large cell transformation (LCT, n = 22). Two-thirds of patients with ASD presented with de novo ASD. The median overall survival (OS) for ASD was 5 years with a 10-year predicted OS of 32%. Age at initial diagnosis (P = .01), tumor stage (P=.01), and clinical stage (P=.001) were found to be significant predictors of outcome. Patients who presented with de novo ASD demonstrated better outcomes that were not statistically significant than those with a prior diagnosis of early-stage MF (P = .25). Transformation developed in 22 of the 297 MF/SS patients (7.4%), with a transformation rate of only 1.4% in patients with early-stage disease, compared with stage IIB (27%) and stage IV (56%-67%) disease. The median OS from diagnosis of LCT was 2 years. We confirm that the incidence of LCT Is strongly dependent on tumor stage at diagnosis, and we demonstrate a much lower overall risk of LCT than previously reported.
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Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation
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Autor/in / Beteiligte Person: | ARULOGUN, Suzanne O ; PRINCE, H. Miles ; NG, Jonathan ; LADE, Stephen ; RYAN, Gail F ; BLEWITT, Odette ; MCCORMACK, Christopher |
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Zeitschrift: | Blood, Jg. 112 (2008), Heft 8, S. 3082-3087 |
Veröffentlichung: | Washington, DC: Americain Society of Hematology, 2008 |
Medientyp: | academicJournal |
Umfang: | print, 16 ref |
ISSN: | 0006-4971 (print) |
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