Telomerase Activity in Head and Neck Cancer
In: Anticancer research, Jg. 28 (2008), Heft 5B, S. 3125-3129
Online
academicJournal
- print, 22 ref
Zugriff:
Background: Telomerase activity is associated with many malignancies, including head and neck cancer. The use of telomerase activity as a diagnostic and prognostic marker of head and neck cancer development was examined and compared with standard histological analysis. Patients and Methods: Telomerase activity was determined using quantitative dual-colour real-time TRAP (telomeric repeat amplification protocol). In each of 58 patients, a sample of tumour tissue, adjacent mucosa and normal muscle was collected. Results: Telomerase activation was observed in 88% of tumour tissues and 34% of tumour-adjacent mucosa samples. No telomerase activity was detected in normal muscle tissues. Telomerase activity correlated with tumour grade, with an average of 4.6 telomerase units (T.U.) in well-differentiated, 8.3 T.U. in moderately-differentiated and 20 T.U. in poorly differentiated tumours. Relapse occurred in 13 patients and no telomerase activity was detected in 3 recurrent tumours. Conclusion: Telomerase activity may be used as an objective parameter inversely related to tumour differentiation. Prognosis in telomerase-negative tumours is worse than that of the telomerase-positive group.
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Telomerase Activity in Head and Neck Cancer
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Autor/in / Beteiligte Person: | KUNICKA, Zuzana ; MUCHA, Igor ; FAJKUS, Jiri |
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Zeitschrift: | Anticancer research, Jg. 28 (2008), Heft 5B, S. 3125-3129 |
Veröffentlichung: | Attiki: International Institute of Anticancer Research, 2008 |
Medientyp: | academicJournal |
Umfang: | print, 22 ref |
ISSN: | 0250-7005 (print) |
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