Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome in the Greek population
In: International journal of obesity, Jg. 32 (2008), Heft 11, S. 1618-1625
Online
academicJournal
- print, 34 ref
Zugriff:
Objective: To investigate the relationship between MKKS gene variations, obesity-related traits and features of the metabolic syndrome (MS) in the Greek population. Design and subjects: Genotype and haplotype analysis was carried out for six known MKKS gene polymorphisms (534C>T, 985 + 16T>G, 985 + 33C>G, 986-29A>T, 1161 + 58A>G and 1595G >T) in 220 obese subjects (body mass index ≥ 30 kg/m2) and 330 non-obese controls. Results: Genotype frequencies of the 985 + 16T>G, 986-29A>T and 1595G>T SNPs were significantly different between obese and non-obese individuals (P= 0.0016, 0.0196 and 0.0069, respectively). Obese carriers of the risk alleles of the above three polymorphisms had a significantly increased prevalence of arterial hypertension. Furthermore, obese carriers of the G allele for the 985 + 16T > G polymorphism had an increased prevalence of type 2 diabetes mellitus and of MS component traits. A new polymorphism was detected, namely a C to T substitution at position 1129 (1129C>Tor N377N). Frequency of the T allele for the 1129C>T polymorphism was significantly higher in control individuals than in obese subjects (P=0.0253). Haplotype TGTGT was more prevalent in obese than in controls (P=0.0002) and was associated with increased prevalence of the MS in obese subjects (P<0.0001). Conclusion: Our results suggest that genetic variation in the MKKS gene may play a role in the development of obesity and the metabolic syndrome.
Titel: |
Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome in the Greek population
|
---|---|
Autor/in / Beteiligte Person: | ROUSKAS, K ; PALETAS, K ; KALOGERIDIS, A ; SARIGIANNI, M ; IOANNIDOU-PAPAGIANNAKI, E ; TSAPAS, A ; KOUVATSI, A |
Link: | |
Zeitschrift: | International journal of obesity, Jg. 32 (2008), Heft 11, S. 1618-1625 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2008 |
Medientyp: | academicJournal |
Umfang: | print, 34 ref |
ISSN: | 0307-0565 (print) |
Schlagwort: |
|
Sonstiges: |
|