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The major component of senile plaques and vascular amyloid in Alzheimer's disease (AD) brains is the amyloid β protein (Ap). Besides Aβ, several other proteins have been identified in these lesions, in particular heparan sulfate proteoglycans (HSPG). However, it is still unclear, what causes the excessive accumulation of HSPG in AD brains. Therefore, we investigated if Aβ may influence production and expression of two major Ap-associated HSPG species, agrin and glypican-1. When human brain pericytes (HBP) were cultured in the presence ofAp, protein and mRNA expression of both agrin and glypican-1 were increased and more radioactive sulfate was incorporated in the glycosaminoglycan fraction ofAp-treated HBP. Furthermore, after Aβ treatment, these HSPG were found in association with the amyloid fibrils attached to the cell membrane, in contrast to the intracellular agrin and glypican-1 staining observed in untreated cells. We conclude that Aβ can modulate the cellular expression of agrin and glypican-1, which may contribute to the accumulation of these HSPG in AD lesions.

Titel:	Amyloid β induces cellular relocalization and production of agrin and glypican-1
Autor/in / Beteiligte Person:	TIMMER, Nienke M ; VAN HORSSEN, Jack ; OTTE-HOLLER, Irene ; WILHELMUS, Micha M. M ; DAVID, Guido ; VAN BEERS, Joyce ; DE WAAL, Rob M. W ; VERBEEK, Marcel M
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Brain research, Jg. 1260 (2009), S. 38-46
Veröffentlichung:	Amsterdam: Elsevier, 2009
Medientyp:	academicJournal
Umfang:	print, 1 p.1/4
ISSN:	0006-8993 (print)
Schlagwort:	Cognition Neurology Neurologie Physiology, morphology Physiologie, morphologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Maladies dégénératives et hérédodégénératives du système nerveux. Leucodystrophies. Maladies à prions Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Psychopathologie. Psychiatrie Psychopathology. Psychiatry Etude clinique de l'adulte et de l'adolescent Adult and adolescent clinical studies Troubles mentaux organiques. Neuropsychologie Organic mental disorders. Neuropsychology Psychologie. Psychanalyse. Psychiatrie Psychology. Psychoanalysis. Psychiatry PSYCHOPATHOLOGIE. PSYCHIATRIE Maladie dégénérative Degenerative disease Enfermedad degenerativa Pathologie de l'encéphale Cerebral disorder Encéfalo patología Pathologie du système nerveux central Central nervous system disease Sistema nervosio central patología Pathologie du système nerveux Nervous system diseases Sistema nervioso patología Système nerveux central Central nervous system Sistema nervioso central Agrine Agrin Agrina Démence d'Alzheimer Alzheimer disease Demencia Alzheimer Encéphale Encephalon Encéfalo Homme Human Hombre Héparitine sulfate Heparitin sulfate Heparitina sulfato Protéine amyloïde β β Amyloid protein Proteína amiloide β Protéoglycane Proteoglycan Proteoglicano Péricyte Pericyte Pericito Alzheimer's disease Amyloid beta Glypican-1 Heparan sulfate proteoglycan Human brain pericyte
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Neurology, Laboratory of Pediatrics and Neurology, Donders Centre for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, 830 LKN, P.O. box 9101, 6500 HB Nijmegen, Netherlands ; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands ; Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands ; Department of Anatomy and Neurosciences, VU University Medical Centre, Amsterdam, Netherlands ; The Center for Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium Rights: Copyright 2009 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Neurology ; Psychopathology. Psychiatry. Clinical psychology ; FRANCIS

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Amyloid β induces cellular relocalization and production of agrin and glypican-1