A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain)
In: Vaccine, Jg. 27 (2009), Heft 10, S. 1540-1548
academicJournal
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Zugriff:
CMV-seronegative subjects vaccinated intramuscularly or intradermally with a DNA vaccine encoding pp65, IE1, and gB were administered live-attenuated CMV (Towne) to characterize immune priming by the DNA vaccine. CMV-specific memory T-cells (detected by standard ELISPOT assay in only 20% of subjects) were detected by IFN-γ cultured ELISPOT assay in 60% of subjects primed intramuscularly and correlated with immune responses after Towne. The median time to first pp65 T-cell and gB antibody response after Towne was 14 days for DNA-primed subjects vs. 28 days for controls administered Towne only (p = 0.02 and 0.03, respectively). Furthermore, there was a trend toward more DNA-vaccinated subjects than controls developing a gB-specific IFN-γ T-cell response after Towne administration (47% vs. 0%, p = 0.06).
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A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain)
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Autor/in / Beteiligte Person: | JACOBSON, Mark A ; ADLER, Stuart P ; SINCLAIR, Elizabeth ; BLACK, Douglas ; SMITH, Anna ; CHU, Alice ; MOSS, Ron B ; WLOCH, Mary K |
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Zeitschrift: | Vaccine, Jg. 27 (2009), Heft 10, S. 1540-1548 |
Veröffentlichung: | Kidlington: Elsevier, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 20 ref |
ISSN: | 0264-410X (print) |
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