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Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10-8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Titel:	Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Autor/in / Beteiligte Person:	WILIER, Cristen J ; SPELIOTES, Elizabeth K ; LETTRE, Guillaume ; LIM, Noha ; LYON, Helen N ; MCCARROLL, Steven A ; PAPADAKIS, Konstantinos ; LU, QI ; RANDALL, Joshua C ; ROCCASECCA, Rosa Maria ; SANNA, Serena ; SCHEET, Paul ; LOOS, Ruth J. F ; WEEDON, Michael N ; WHEELER, Eleanor ; JING HUA, ZHAO ; JACOBS, Leonie C ; PROKOPENKO, Inga ; SORANZO, Nicole ; TANAKA, Toshiko ; TIMPSON, Nicholas J ; ALMGREN, Peter ; BENNETT, Amanda ; SHENGXU, LI ; BERGMAN, Richard N ; BINGHAM, Sheila A ; BONNYCASTLE, Lori L ; BROWN, Morris ; BURTT, Noël P ; CHINES, Peter ; COIN, Lachlan ; COLLINS, Francis S ; CONNELL, John M ; COOPER, Cyrus ; LINDGREN, Cecilia M ; SMITH, George Davey ; DENNISON, Elaine M ; DEODHAR, Parimal ; ELLIOTT, Paul ; ERDOS, Michael R ; ESTRADA, Karol ; EVANS, David M ; GIANNINY, Lauren ; GIEGER, Christian ; GILLSON, Christopher J ; HEID, Iris M ; GUIDUCCI, Candace ; HACKETT, Rachel ; HADLEY, David ; HALL, Alistair S ; HAVULINNA, Aki S ; HEBEBRAND, Johannes ; HOFMAN, Albert ; ISOMAA, Bo ; JACOBS, Kevin B ; JOHNSON, Toby ; BERNDT, Sonja I ; ELLOTT, Amanda L ; JACKSON, Anne U ; LAMINA, Claudia ; Consortiwn, GIANT
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Nature genetics, Jg. 41 (2009), Heft 1, S. 25-34
Veröffentlichung:	New York, NY: Nature Publishing Group, 2009
Medientyp:	academicJournal
Umfang:	print, 49 ref
ISSN:	1061-4036 (print)
Schlagwort:	Genetics Génétique Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Genetique des eucaryotes. Evolution biologique et moleculaire Genetics of eukaryotes. Biological and molecular evolution Indice masse corporelle Body mass index Indice masa corporal Locus Neurone Neuron Neurona Poids corporel Body weight Peso corporal Régulation Regulation(control) Regulación
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, United States ; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States ; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts 02142, United States ; Program in Genomics and Divisions of Endocrinology and Genetics, Children's Hospital, Boston, Massachusetts 02115, United States ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States ; Medical Genetics/Clinical Pharmacology and Discovery Medicine, King of Prussia, Pennsylvania 19406, United States ; Department of Molecular Biology, Massachusetts General Hospital, Cambridge, Massachusetts 02144, United States ; Division of Community Health Sciences, St. George's, University of London, London SW17 ORE, United Kingdom ; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, United States ; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom ; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 ISA, United Kingdom ; Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari 09042, Italy ; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, United States ; Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Cambridge CB2 OQQ, United Kingdom ; Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, United Kingdom ; Genetics of Complex Traits, Peninsula Medical School, Exeter EX1 2LU, United Kingdom ; Department of Internal Medicine, Erasmus MC, PO Box 2400, 3000-CA Rotterdam, Netherlands ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7U, United Kingdom ; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, United Kingdom ; National Institute of Aging, Clinical Research Branch -Longitudinal Studies Section, Baltimore, Maryland 21225, United States ; MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol BS8 2PR, United Kingdom ; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden ; Institute of Epidemiology, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States Rights: Copyright 2009 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Eukaryotes genetics. Biological and molecular evolution

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation