Prophylaxis Versus Preemptive Anti-cytomegalovirus Approach for Prevention of Allograft Vasculopathy in Heart Transplant Recipients
In: The Journal of heart and lung transplantation, Jg. 28 (2009), Heft 5, S. 461-467
academicJournal
- print, 36 ref
Zugriff:
Background: Cytomegalovirus (CMV) infection may influence the development of cardiac allograft vasculopathy (CAV). Prophylactic or preemptive administration of anti-CMV agents effectively prevents acute CMV manifestations. However, studies comparing allograft-related outcomes between these anti-CMV approaches are lacking. Herein we report a longitudinal observational study comparing CAV development between prophylactic and preemptive approaches. Methods: The 1-year change in maximal intimal thickening (MIT) assessed by intravascular ultrasound at 1 and 12 months after heart transplantation (the major surrogate for late survival) was compared in groups of patients routinely assigned to a preemptive strategy (from November 2004 to October 2005; n = 21) or receiving valganciclovir prophylaxis (from November 2005 to October 2006; n = 19). CMV infection was monitored with pp65 antigenemia. Results: The 1-year increase in MIT was significantly lower in patients receiving prophylaxis compared with those managed preemptively (0.15 ± 0.17 vs 0.31 ± 0.20 mm; p = 0.01). Prophylaxed recipients presented less frequently with MIT change ≥0.3 mm (p = 0.03) and ≥0.5 mm (p = 0.10) than those managed preemptively. Prophylaxis was also associated with later onset of CMV infection (p = 0.01), lower peak CMV detection (p < 0.01) and reduced incidence of CMV disease/syndrome (p = 0.04). After adjusting for metabolic risk factors and other possible confounders, prophylaxis remained independently associated with lower risk for MIT change ≥0.3 mm (odds ratio = 0.09, 95% confidence interval 0.01 to 0.93; p = 0.04). Conclusions: Universal prophylaxis was associated with delayed onset of CMV infection, lower viral burden, reduced CMV disease/syndrome and less intimal thickening, as compared with a preemptive anti-CMV approach. Randomized studies are required to confirm the potential benefits of prophy- laxis vs a preemptive approach in heart transplant recipients.
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Prophylaxis Versus Preemptive Anti-cytomegalovirus Approach for Prevention of Allograft Vasculopathy in Heart Transplant Recipients
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Autor/in / Beteiligte Person: | POTENA, Luciano ; GRIGIONI, Francesco ; MAGNANI, Gaia ; LAZZAROTTO, Tiziana ; MUSURACA, Anna C ; ORTOLANI, Paolo ; COCCOLO, Fabio ; FALLANI, Francesco ; RUSSO, Antonio ; BRANZI, Angelo |
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Zeitschrift: | The Journal of heart and lung transplantation, Jg. 28 (2009), Heft 5, S. 461-467 |
Veröffentlichung: | New York, NY: Elsevier, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 36 ref |
ISSN: | 1053-2498 (print) |
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