Cytomegalovirus Shedding and Delayed Sensorineural Hearing Loss: Results From Longitudinal Follow-up of Children With Congenital Infection
In: The Pediatric infectious disease journal, Jg. 28 (2009), Heft 6, S. 515-520
Online
academicJournal
- print, 25 ref
Zugriff:
Background: The pathogenesis of cytomegalovirus (CMV)-related hearing loss is not well understood. Objective: To evaluate the relationship between persistent CMV shedding and delayed sensorineural hearing loss in children born with congenital CMV. Methods: Serial audiologic assessments and CMV cultures of urine and saliva were performed on 580 children who had been diagnosed with congenital CMV infection. Results: Prevalence of CMV culture-positivity in any specimen decreased to approximately 50% by the third birthday and approximately 5% after the seventh birthday. Intermittent shedding occurred in 28% of children. Seventy-seven children had hearing loss at birth and 38 children developed delayed hearing loss by the end of follow-up. In multivariate analyses, delayed hearing loss was strongly associated with symptomatic infection at birth (OR = 5.9, 95% CI: 1.8―18.9) and modestly associated with older age at last culture-positive visit (OR = 1.6, 95% CI: 1.1―2.0, comparing 1-year age differences) Observed rates of delayed hearing loss were 0.79 per 100 person-years for children asymptomatic at birth and 4.29 per 100 person-years for children symptomatic at birth. Between the ages of 6 months and 8 years, we would expect delayed hearing loss to occur in 6.9% of asymptomatic children and in 33.7% of symptomatic children. Conclusions: The strongest risk factor for delayed hearing loss was CMV-related symptoms at birth, but many asymptomatic children also developed delayed hearing loss. Longer duration of CMV shedding may also be a predictor of delayed hearing loss.
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Cytomegalovirus Shedding and Delayed Sensorineural Hearing Loss: Results From Longitudinal Follow-up of Children With Congenital Infection
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Autor/in / Beteiligte Person: | ROSENTHAL, Lauren Stancik ; FOWLER, Karen B ; BOPPANA, Suresh B ; BRITT, William J ; PASS, Robert F ; SCHMID, Scott D ; STAGNO, Sergio ; CANNON, Michael J |
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Zeitschrift: | The Pediatric infectious disease journal, Jg. 28 (2009), Heft 6, S. 515-520 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 25 ref |
ISSN: | 0891-3668 (print) |
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