Activity of levofloxacin and ciprofloxacin on biofilms and planktonic cells of Stenotrophomonas maltophilia isolates from patients with device-associated infections

PASSERINI DE ROSSI, B ; GARCIA, C ; et al.

In: International journal of antimicrobial agents (Print), Jg. 34 (2009), Heft 3, S. 260-264

academicJournal - print, 15 ref

The aim of this work was to compare the in vitro effects of levofloxacin and ciprofloxacin on pre-formed biofilms and planktonic populations of Stenotrophomonas maltophilia isolates from device-associated infections recovered over the period 2004-2008 at a university hospital in Argentina. For planktonic susceptibility studies, the minimum inhibitory concentrations (MICs) of fluoroquinolones were determined by the broth microdilution method. From the 32 isolates recovered, 84.4% were sensitive to levofloxacin and 43.8% were sensitive to ciprofloxacin. Biofilm susceptibility was evaluated by the minimum re-growth concentration (MRC) assay. Stenotrophomonas maltophilia isolates sensitive to fluoroquinolones according to their MICs were highly resistant according to the MRC values. Thus, currently used concentrations of fluoroquinolones cannot be used in monotherapy for eradication of a biofilm. Nevertheless, these agents could be used for the lock technique. Interestingly, for some isolates fluoroquinolone concentrations achievable during therapy caused a reduction in viable cells of99% and promoted disruption of biofilms, evaluated by spectrophotometric and microscopic analysis. These results suggest that fluoroquinolones, particularly levofloxacin due to its better pharmacokinetic parameters, are candidates for synergy studies.

Titel:	Activity of levofloxacin and ciprofloxacin on biofilms and planktonic cells of Stenotrophomonas maltophilia isolates from patients with device-associated infections
Autor/in / Beteiligte Person:	PASSERINI DE ROSSI, B ; GARCIA, C ; CALENDA, M ; VAY, C ; FRANCO, M
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	International journal of antimicrobial agents (Print), Jg. 34 (2009), Heft 3, S. 260-264
Veröffentlichung:	Amsterdam: Elsevier, 2009
Medientyp:	academicJournal
Umfang:	print, 15 ref
ISSN:	0924-8579 (print)
Schlagwort:	Microbiology, infectious diseases Microbiologie, maladies infectieuses Pharmacology drugs Pharmacologie, galénique Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Antibiotiques. Antiinfectieux. Antiparasitaires Antibiotics. Antiinfectious agents. Antiparasitic agents Bactérie Bacteria Dérivé de la fluoroquinolone Fluoroquinolone derivatives Fluoroquinolone derivado Dérivé de la quinolone Quinolone derivatives Quinolone derivado Pseudomonadaceae Pseudomonadales Activité biologique Biological activity Actividad biológica Antibactérien Antibacterial agent Antibacteriano Biofilm Cellule Cell Célula Ciprofloxacine Ciprofloxacin Ciprofloxacino Dispositif Device Dispositivo Homme Human Hombre In vitro Infection Infección Isolat Isolate Aislado Lévofloxacine Levofloxacin Levofloxacino Malade Patient Enfermo Sensibilité Sensitivity Sensibilidad Stenotrophomonas maltophilia Biofilm susceptibility Device-associated infections
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires Junín 956, 1113 Buenos Aires, Argentina ; Laboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martin, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Av. Cordoba 2351, 1120 Buenos Aires, Argentina Rights: Copyright 2009 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pharmacological treatments

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