Fungal Infections in Pediatric Lung Transplant Recipients: Colonization and Invasive Disease
In: The Journal of heart and lung transplantation, Jg. 28 (2009), Heft 11, S. 1226-1230
academicJournal
- print, 22 ref
Zugriff:
Background: The purpose of this study was to evaluate the epidemiology and investigate the impact of colonization and pulmonary fungal infections (PFIs). Methods: In this investigation we performed a retrospective analysis of 55 pediatric lung transplant recipients from 2002 to 2007 at a single institution. Associations between risk factors and time to post-transplant colonization, PFI, and other outcomes were assessed using Cox proportional hazard models. Results: Although 29 patients had positive pre-transplant colonization, 33 (60%) were colonized post-transplant and 20% (11 subjects) developed proven or probable PFI. In a multivariate model, post-transplant fungal colonization was associated with older age (hazard ratio [HR] 2.9, 95% confidence interval [CI] 1.1 to 7.6), cytomegalovirus (CMV) prophylaxis (HR 5.6, 95% CI 1.3 to 24.6) and respiratory viral infection prior to fungal colonization (HR 2.9, 95% CI 1.0 to 8.3). Conclusion: Neither fungal colonization nor PFI was associated with the development of chronic allograft rejection or death.
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Fungal Infections in Pediatric Lung Transplant Recipients: Colonization and Invasive Disease
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Autor/in / Beteiligte Person: | LIU, Michael ; WORLEY, Sarah ; MALLORY, George B ; ARRIGAIN, Sarah ; ROBERTSON, John ; SCHECTER, Marc G ; ELIDEMIR, Okan ; DANZIGER-ISAKOV, Lara A |
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Zeitschrift: | The Journal of heart and lung transplantation, Jg. 28 (2009), Heft 11, S. 1226-1230 |
Veröffentlichung: | New York, NY: Elsevier, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 22 ref |
ISSN: | 1053-2498 (print) |
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