Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment
In: Dementia and geriatric cognitive disorders, Jg. 28 (2009), Heft 4, S. 348-356
Online
academicJournal
- print, 42 ref
Zugriff:
Background: Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies. Aim: The aim of the study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total tau (T-tau), amyloid β1-42 (Aβ42) and neurofilament light (NF-L) in patients with MCI could predict subcortical vascular dementia (SVD) and Alzheimer's disease (AD) at follow-up. Methods: Biomarker levels were assessed by Luminex xMAP technology and ELISA. Results: Increased baseline concentrations of NF-L significantly separated MCI-SVD from stable MCI. The MCI-SVD patients were inseparable from stable MCI but separable from patients developing AD (MCI-AD) on the basis of Aβ42, T-tau and P-tau181 levels. Conclusion: A combination of the biomarkers Aβ42, T-tau, P-tau181, and NF-L has the potential to improve the clinical separation of MCI-SVD patients from stable MCI and MCI-AD patients.
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Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment
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Autor/in / Beteiligte Person: | BJERKE, Maria ; ANDREASSON, Ulf ; ROLSTAD, Sindre ; NORDLUND, Arto ; LIND, Karin ; ZETTERBERG, Henrik ; EDMAN, Ake ; BLENNOW, Kaj ; WALLIN, Anders |
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Zeitschrift: | Dementia and geriatric cognitive disorders, Jg. 28 (2009), Heft 4, S. 348-356 |
Veröffentlichung: | Basel: Karger, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 42 ref |
ISSN: | 1420-8008 (print) |
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