Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent
In: Journal of medicinal chemistry (Print), Jg. 52 (2009), Heft 23, S. 7873-7877
academicJournal
- print, 28 ref
Zugriff:
Naphthalimmide (NI) and 1,4,5,8-naphthalentetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity. NDI derivatives 1—9 were more cytotoxic than the corresponding NI derivatives 10—18. The molecular mechanisms of 1 and 2 were investigated in comparison to mitonafide. They interacted with DNA, were not topoisomerase IIα poisons, triggered caspase activation, caused p53 protein accumulation, and down-regulated AKT survival. Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation.
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Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent
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Autor/in / Beteiligte Person: | TUMIATTI, Vincenzo ; MILELLI, Andrea ; STEFANELLI, Claudio ; MELCHIORRE, Carlo ; MINARINI, Anna ; MICCO, Marialuisa ; GASPERI CAMPANI, Anna ; RONCUZZI, Laura ; BAIOCCHI, Daniela ; MARINELLO, Jessica ; CAPRANICO, Giovanni ; ZINI, Maddalena |
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Zeitschrift: | Journal of medicinal chemistry (Print), Jg. 52 (2009), Heft 23, S. 7873-7877 |
Veröffentlichung: | Columbus, OH: American Chemical Society, 2009 |
Medientyp: | academicJournal |
Umfang: | print, 28 ref |
ISSN: | 0022-2623 (print) |
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