Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features
In: Behavioural brain research, Jg. 207 (2010), Heft 2, S. 476-479
academicJournal
- print, 37 ref
Zugriff:
Animal models allow insights into complex neurodevelopmental disorders. Apomorphine-susceptible rats (so-called APO-SUS rats) provide a model that displays a complex phenotype with schizophrenia-related features and together with its phenotypic counterpart (APO-UNSUS rats) has been independently generated twice (original and replicate rat lines). To understand the molecular basis underlying this phenotype, we here performed mRNA expression profiling in various APO-SUS and APO-UNSUS rat brain regions. The expression of only the previously reported Aph-1b and the newly discovered KCnIP1 (a member of the potassium channel-interacting protein family that is known to modulate neuronal channel activity) was significantly different in the APO-SUS and APO-UNSUS rats from both the original and replicate rat lines. Thus, KCnIP1 may constitute a novel candidate gene playing a role in the complex phenotype of the APO-SUS/APO-UNSUS rat model and further studies on this gene are warranted.
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Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features
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Autor/in / Beteiligte Person: | VAN SCHIJNDEL, Jessica E ; VAN ZWEEDEN, Martine ; VAN LOO, Karen M. J ; MARTENS, Gerard J. M |
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Zeitschrift: | Behavioural brain research, Jg. 207 (2010), Heft 2, S. 476-479 |
Veröffentlichung: | Shannon: Elsevier, 2010 |
Medientyp: | academicJournal |
Umfang: | print, 37 ref |
ISSN: | 0166-4328 (print) |
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