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Purpose: Alterations in dopamine neurotransmission in animal models of epilepsies have been frequently demonstrated using invasive neuroscience or ex vivo techniques. We aimed to test whether corresponding alterations could be detected by noninvasive in vivo brain imaging with positron emission tomography (PET) in the chronic phase of the rat pilocarpine model of temporal lobe epilepsy. Methods: Six pilocarpine-treated Wistar rats exhibiting spontaneous recurrent seizures and nine control rats were studied with PET using [18F]-fallypride, a high-affinity dopamine D2/3 receptor ligand. Parametric images of [18F]-fallypride specific binding were calculated using a reference tissue method, and the two groups were contrasted by whole-brain voxel-based analysis implemented in statistical parametric mapping (SPM5). Results: Dopamine D2/3 receptor availability was 27% lower in the bilateral anterior caudate-putamen of pilocarpine-treated rats as compared to controls (p < 0.05), but binding was unaffected in other striatal or extrastriatal regions. Conclusions: The finding of substantially reduced availability of dopamine D2/3 receptors in the anterior caudate-putamen of rats during the chronic phase of the pilocarpine model is in agreement with results of invasive (microinjection, micro-dialysis) animal studies that have revealed increased dopamine tonus and a D2/3 receptor-mediated anticonvulsant action of dopamine in the anterior segment of the rat striatum. The present PET approach could be prospectively applied for monitoring dopamine receptor changes longitudinally, that is, at different phases of the epileptogenic process, and opens perspectives for testing dopaminergic agents as potential antiepileptogenic drugs.

Titel:	In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy
Autor/in / Beteiligte Person:	YAKUSHEV, Igor Y ; DUPONT, Erwan ; WERHAHN, Konrad J ; SCHRECKENBERGER, Mathias ; POTSCHKA, Heidrun ; BARTENSTEIN, Peter ; BUCHHOLZ, Hans-Georg ; TILLMANNS, Julia ; DEBUS, Fabian ; CUMMING, Paul ; HEIMANN, Axel ; FELLGIEBEL, Andreas ; LUHMANN, Heiko J ; LANDVOGT, Christian
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Epilepsia (Copenhagen), Jg. 51 (2010), Heft 3, S. 415-422
Veröffentlichung:	Malden, MA: Wiley-Blackwell, 2010
Medientyp:	academicJournal
Umfang:	print, 1 p.1/2
ISSN:	0013-9580 (print)
Schlagwort:	Neurology Neurologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Neuropharmacologie Neuropharmacology Anticonvulsivants. Antiépileptiques. Antiparkinsoniens Anticonvulsants. Antiepileptics. Antiparkinson agents Système nerveux (sémiologie, syndromes) Nervous system (semeiology, syndromes) Syndromes encéphaliques généraux: céphalées, douleurs de la face, syncopes, épilepsie, hypertension intracrânienne, oedème cérébral. Infirmité motrice cérébrale Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Agoniste Agonist Agonista Catécholamine Catecholamine Catecolamina Dérivé du furane Furan derivatives Furano derivado Epilepsie partielle complexe Complex partial epilepsy Epilepsia parcial compleja Neurotransmetteur Neurotransmitter Neurotransmisor Parasympathomimétique Parasympathomimetic Parasimpatomimético Pathologie de l'encéphale Cerebral disorder Encéfalo patología Pathologie du système nerveux central Central nervous system disease Sistema nervosio central patología Récepteur cholinergique Cholinergic receptor Receptor colinérgico Récepteur muscarinique Muscarinic receptor Receptor muscarínico Animal Antiglaucomateux Antiglaucomatous agent Antiglaucomatoso Dopamine Dopamina Epilepsie temporale Temporal lobe epilepsy Epilepsia temporal Modèle Models Modelo Pathologie du système nerveux Nervous system diseases Sistema nervioso patología Pilocarpine Pilocarpina Récepteur dopaminergique D2 D2 Dopamine receptor Receptor dopaminérgico D2 Récepteur dopaminergique Dopamine receptor Receptor dopaminérgico Tomographie par émission de positons Positron emission tomography Tomografía emisión positrones Tomoscintigraphie Emission tomography Tomocentelleografía Animal PET D2/3 receptors Fallypride Pilocarpine model
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Labor de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille, Lille, France ; Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany ; Department of Nuclear Medicine, University of Mainz, Mainz, Germany ; Institute of Pharmacology, Toxicology and Pharmacy, University of Munich (LMU), Munich, Germany ; Department of Nuclear Medicine, University of Munich (LMU), Munich, Germany ; Department of Psychiatry, University of Mainz, Mainz, Germany ; Institute for Neurosurgical Pathophysiology, University of Mainz, Mainz, Germany ; Department of Neurology, University of Mainz, Mainz, Germany Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Neurology ; Pharmacological treatments ; Psychopathology. Psychiatry. Clinical psychology

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In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy