Costs and Consequences Associated With Newer Medications for Glycemic Control in Type 2 Diabetes
In: Diabetes care, Jg. 33 (2010), Heft 4, S. 695-700
Online
academicJournal
- print, 36 ref
Zugriff:
OBJECTIVE - Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for patients with new-onset diabetes. RESEARCH DESIGN AND METHODS- We performed a cost-effectiveness analysis for the U.S. population aged 25-64. A lifetime analytic horizon and health care system perspective were used. Costs and quality-adjusted life years (QALYs) were discounted at 3% annually, and costs are presented in 2008 U.S. dollars. We compared three glycemic control strategies: 1) glyburide as a second-line agent, 2) exenatide as a second-line agent, and 3) sitagliptin as a second-line agent. Outcome measures included QALYs gained, incremental costs, and the incremental cost-effectiveness ratio associated with each strategy. RESULTS- Exenatide and sitagliptin conferred 0.09 and 0.12 additional QALYs, respectively, relative to glyburide as second-line therapy. In base case analysis, exenatide was dominated (cost more and provided fewer QALYs than the next most expensive option), and sitagliptin was associated with an incremental cost-effectiveness ratio of $169,572 per QALY saved. Results were sensitive to assumptions regarding medication costs, side effect duration, and side effect-associated disutilities. CONCLUSIONS- Exenatide and sitagliptin may confer substantial costs to health care systems. Demonstrated gains in quality and/or quantity of life are necessary for these agents to provide economic value to patients and health care systems.
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Costs and Consequences Associated With Newer Medications for Glycemic Control in Type 2 Diabetes
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Autor/in / Beteiligte Person: | SINHA, Anushua ; RAJAN, Mangala ; HOERGER, Thomas ; POGACH, Len |
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Zeitschrift: | Diabetes care, Jg. 33 (2010), Heft 4, S. 695-700 |
Veröffentlichung: | Alexandria, VA: American Diabetes Association, 2010 |
Medientyp: | academicJournal |
Umfang: | print, 36 ref |
ISSN: | 0149-5992 (print) |
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